CAJ | 학술논문

作为一种重要的神经递质，腺苷能通过与细胞膜上的腺苷受体（adenosine receptors，AR）结合而发挥细胞调节作用。 AR属于G蛋白偶联受体家族，哺乳动物的AR至少包含A1、A2A、A2B和A3等4个亚型，其中A2A受体与多种临床疾病的发生、发展都有着密切的关系。本文主要综述了A2A受体与多种神经精神疾病之间关系的研究进展，以期为这些疾病的防治研究提供新的线索。
작위일충중요적신경체질，선감능통과여세포막상적선감수체（adenosine receptors，AR）결합이발휘세포조절작용。 AR속우G단백우련수체가족，포유동물적AR지소포함A1、A2A、A2B화A3등4개아형，기중A2A수체여다충림상질병적발생、발전도유착밀절적관계。본문주요종술료A2A수체여다충신경정신질병지간관계적연구진전，이기위저사질병적방치연구제공신적선색。
Adenosine, which arises from the breakdown of adenosine triphosphate, is extensively distributed in mammalian tis-sues and cells. Adenosine exerts its regulating effects on cell function via binding to the specific membrane receptors. Adenosine receptors are belong to G-protein-coupled receptors and can be subdivided into A1, A2A, A2B and A3 receptors in mammals. Among these receptors, A2A has been demonstrated to be related to pathogenesis of many diseases. In the present review, we focus on the recent progress made in investigating the relationship between A2A and nervous system disorders, which may provide new strategies for treatment of these diseases.