CAJ | 학술논문

急性早幼粒细胞白血病是急性粒细胞白血病的一个亚型。它的分子生物学特征为15号染色体上的早幼粒细胞白血病（PML）基因与17号染色体上的维A酸受体α（RARα）基因发生易位，表达PML-RARα融合蛋白。 PML-RARα融合蛋白在急性早幼粒细胞白血病的发生、发展、诊断和治疗中发挥着重要作用。本文主要综述PML蛋白的结构和生物学功能，PML-RARα的结构、功能及其降解途径。
급성조유립세포백혈병시급성립세포백혈병적일개아형。타적분자생물학특정위15호염색체상적조유립세포백혈병（PML）기인여17호염색체상적유A산수체α（RARα）기인발생역위，표체PML-RARα융합단백。 PML-RARα융합단백재급성조유립세포백혈병적발생、발전、진단화치료중발휘착중요작용。본문주요종술PML단백적결구화생물학공능，PML-RARα적결구、공능급기강해도경。
Acute promyelocytic leukemia (APL) is a distinctive subtype of acute myeloid leukemia with a distinct biology and clinical presentation. Its molecular biology characteristic is a aberrant chromosomal translocation of the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor α(RARα) gene on chromosome 17. This translocation generates PML-RARα fusion protein, which plays an important role in the genesis, development, diagnosis and therapy of APL. The PML protein has a close relationship with PML-RARαfusion gene. This article mainly summarizes the character, the function of PML protein and the degradation pathway of PML-RARα.