中国医药
中國醫藥
중국의약
CHINA MEDICINE
2009年
12期
968-970
,共3页
苏保鑫%李淑翠%王贵年%刘继涛%陈群
囌保鑫%李淑翠%王貴年%劉繼濤%陳群
소보흠%리숙취%왕귀년%류계도%진군
冠状动脉粥样硬化性心脏病%胆红素%同型半胱氨酸%高敏C反应蛋白
冠狀動脈粥樣硬化性心髒病%膽紅素%同型半胱氨痠%高敏C反應蛋白
관상동맥죽양경화성심장병%담홍소%동형반광안산%고민C반응단백
Coronary heart disease%Bilirubin%Homocysteine%High-sensitive c-reactive protein
目的 探讨冠心病患者血清抗氧化因子总胆红素(TBIL)、促氧化因子同型半胱氨酸(Hcy)和炎症因子高敏C反应蛋白(hs-CRP)水平变化及其临床意义.方法 采用全自动生化分析仪检测20例急性心肌梗死(AMI)组、37例不稳定型心绞痛(UAP)组、85例稳定型心绞痛(SAP)组以及80例健康对照组血清TBIL、Hcy以及hs-CRP含量,建立Logistic回归分析冠心病发生的危险因素.结果 冠心病患者中AMI组、UAP组和SAP组TBIL含量分别为(12.1±3.0)μmol/L,(11.5±2.2)μmol/L,(9.0±1.9)μmol/L,均低于正常对照组[(13.8±3.6)μmol/L](P<0.05);此3组Hcy含量分别为(21.3±4.6)μmol/L,(19.4±4.1)μmol/L,(14.8±3.9)μmol/L,均高于正常对照组[(9.7±3.5)μmol/L](P<0.05);且冠心病各组间TBIL和Hcy含最变化密切正相关.但是hs-CRP含量AMI和UAP组分别为(4.82±1.07)mg/L和(1.33±0.33)mg/L,高于SAP组和对照组[(0.94±0.23)mg/L和(0.89±0.24)mg/L],而SAP组和对照组间hs-CRP水平没有差别.结论 冠心病患者血清TBIL和Hcy水平呈现出一定相关性,对评估冠心病各临床分型鉴别有一定临床价值;hs-CRP在AMI和UAP患者血清中明显升高,可作为它们风险的独立评价指标.
目的 探討冠心病患者血清抗氧化因子總膽紅素(TBIL)、促氧化因子同型半胱氨痠(Hcy)和炎癥因子高敏C反應蛋白(hs-CRP)水平變化及其臨床意義.方法 採用全自動生化分析儀檢測20例急性心肌梗死(AMI)組、37例不穩定型心絞痛(UAP)組、85例穩定型心絞痛(SAP)組以及80例健康對照組血清TBIL、Hcy以及hs-CRP含量,建立Logistic迴歸分析冠心病髮生的危險因素.結果 冠心病患者中AMI組、UAP組和SAP組TBIL含量分彆為(12.1±3.0)μmol/L,(11.5±2.2)μmol/L,(9.0±1.9)μmol/L,均低于正常對照組[(13.8±3.6)μmol/L](P<0.05);此3組Hcy含量分彆為(21.3±4.6)μmol/L,(19.4±4.1)μmol/L,(14.8±3.9)μmol/L,均高于正常對照組[(9.7±3.5)μmol/L](P<0.05);且冠心病各組間TBIL和Hcy含最變化密切正相關.但是hs-CRP含量AMI和UAP組分彆為(4.82±1.07)mg/L和(1.33±0.33)mg/L,高于SAP組和對照組[(0.94±0.23)mg/L和(0.89±0.24)mg/L],而SAP組和對照組間hs-CRP水平沒有差彆.結論 冠心病患者血清TBIL和Hcy水平呈現齣一定相關性,對評估冠心病各臨床分型鑒彆有一定臨床價值;hs-CRP在AMI和UAP患者血清中明顯升高,可作為它們風險的獨立評價指標.
목적 탐토관심병환자혈청항양화인자총담홍소(TBIL)、촉양화인자동형반광안산(Hcy)화염증인자고민C반응단백(hs-CRP)수평변화급기림상의의.방법 채용전자동생화분석의검측20례급성심기경사(AMI)조、37례불은정형심교통(UAP)조、85례은정형심교통(SAP)조이급80례건강대조조혈청TBIL、Hcy이급hs-CRP함량,건립Logistic회귀분석관심병발생적위험인소.결과 관심병환자중AMI조、UAP조화SAP조TBIL함량분별위(12.1±3.0)μmol/L,(11.5±2.2)μmol/L,(9.0±1.9)μmol/L,균저우정상대조조[(13.8±3.6)μmol/L](P<0.05);차3조Hcy함량분별위(21.3±4.6)μmol/L,(19.4±4.1)μmol/L,(14.8±3.9)μmol/L,균고우정상대조조[(9.7±3.5)μmol/L](P<0.05);차관심병각조간TBIL화Hcy함최변화밀절정상관.단시hs-CRP함량AMI화UAP조분별위(4.82±1.07)mg/L화(1.33±0.33)mg/L,고우SAP조화대조조[(0.94±0.23)mg/L화(0.89±0.24)mg/L],이SAP조화대조조간hs-CRP수평몰유차별.결론 관심병환자혈청TBIL화Hcy수평정현출일정상관성,대평고관심병각림상분형감별유일정림상개치;hs-CRP재AMI화UAP환자혈청중명현승고,가작위타문풍험적독립평개지표.
Objective To evaluate the changes of serum total bilirubin (TBIL), homocysteine (Hcy) and high-sensitive c-reactive protein(hs-CRP) in patients with the coronary heart disease (CHD). Methods Concen-trations of the serum TBIL, Hcy and hs-CRP of control group and CHD group were detected by enzymatic cycling method and turbidimetry. All the CHD patients were individed into three groups: 20 acute myocardial infrcion (AMI), 37 unstable angina pectioris(UAP) and 85 stable angina pectoris(SAP). There were 80 normal controls. Results The levels of TBIL in three CHD groups were all lower than those in control group(P<0.05). Hcy levels were higher than those in control groups (P<0.05). The levels of hs-CRP in AMI and UAP groups were higher than those in SAP and control groups(P<0.05). There was a positive correlation between TSIL and Hcy in all three groups of CHD. Conclusion The changes of TBIL and Hcy help distinguish the types of CHD. Meanwhile the in-crease of hs-CRP level can be used as a risk factor for AMI and UAP patients.
