CAJ | 학술논문

目的：探讨不同方法在治疗海军部队人员功能性消化不良( functional dyspepsia, FD)的疗效及临床意义。方法我院2007年6月-2011年12月筛选临床诊断FD 3084例,采用分层抽样法随机选取250例,分为5组,每组50例。 A组给予常规抑酸联合促胃肠动力治疗,B组给予单纯抗抑郁焦虑治疗,C组根据辨证分型给予中药治疗,D组采用起搏器治疗,E组给予安慰剂治疗。比较5组治疗前后临床症状评分改善情况及各临床因素间的交互作用。结果 A~D组治疗1、2、4周后临床症状评分均较治疗前降低,且A、C组改善程度明显优于其余3组,A组治疗效果时间间隔短于其余4组。析因试验方差分析显示不同治疗方法、不同治疗时间因素间均存在显著性差异(F=184.970、167.597,P=0．000)；同时治疗方法-治疗时间因素间存在显著性的交互效应(F=10.510,P=0．000)。结论不同治疗方法对海军部队人员FD均有不同程度临床疗效,但常规西药治疗临床症状缓解时间间隔及总体治疗效果优于其他治疗方法。
목적：탐토불동방법재치료해군부대인원공능성소화불량( functional dyspepsia, FD)적료효급림상의의。방법아원2007년6월-2011년12월사선림상진단FD 3084례,채용분층추양법수궤선취250례,분위5조,매조50례。 A조급여상규억산연합촉위장동력치료,B조급여단순항억욱초필치료,C조근거변증분형급여중약치료,D조채용기박기치료,E조급여안위제치료。비교5조치료전후림상증상평분개선정황급각림상인소간적교호작용。결과 A~D조치료1、2、4주후림상증상평분균교치료전강저,차A、C조개선정도명현우우기여3조,A조치료효과시간간격단우기여4조。석인시험방차분석현시불동치료방법、불동치료시간인소간균존재현저성차이(F=184.970、167.597,P=0．000)；동시치료방법-치료시간인소간존재현저성적교호효응(F=10.510,P=0．000)。결론불동치료방법대해군부대인원FD균유불동정도림상료효,단상규서약치료림상증상완해시간간격급총체치료효과우우기타치료방법。
Objective To explore the curative effects and clinical significance of different methods in treatment of functional dyspepsia ( FD) in naval personnel. Methods A total of 250 patients were randomly selected from screen-ing and clinical diagnosing 3084 FD patients during June 2007 and December 2011 by stratified sampling method, and were divided into 5 groups (each n=50). Group A was treated with conventional acid-suppressing combined with promo-tion of gastrointestinal motility;group B was given a simple antidepressant and antianxiety treatments;group C was treated with traditional Chinese medicine therapy according to the zheng differentiation-classification;group D was given a pace-maker;group E received a placebo treatment. Changes of quantifying scores for clinical symptoms and interaction of clini-cal factors before and after treatment in the 5 groups were compared. Results The quantifying scores for clinical symp-toms after treatment for 1 week, 2 weeks and 4 weeks in group A, B, C and D were decreased, compared with those be-fore treatment, and the improvement in group A and C was better than those in group B, D and E, and the interval of treatment effectiveness in group A was shorter than those in other 4 groups. Factorial experimental variance analysis showed that there were significant differences with different treatment methods in different times ( F = 184. 9701, 167. 597, P=0. 000 ); there was a significant interaction between treatment methods and time ( F =10. 510, P =0. 000 ) . Conclusion Different methods in treatment of FD in naval forces may achieve different levels of clinical effica-cy, while interval of symptomatic relief and total treatment effectiveness by conventional Western medicine may be better than that by the other methods.