CAJ | 학술논문

目的：探讨氨基末端B型利钠肽前体( N-terminal-pro-B-type natriuretic peptide, NT-proBNP)在诊断心源性胸腔积液中的临床价值。方法检索Pubmed、Embase、中国知网、万方、维普等数据库,收集利用NT-proBNP诊断心源性胸腔积液文献并提取数据进行meta分析。结果共有15篇文献1892例研究对象纳入本次meta分析,分析结果显示NT-proBNP对心源性胸腔积液的综合诊断价值分别为：敏感度为0.91(95%CI：0.89,0.93),特异度为0.89(95%CI：0.87,0.90),阳性似然比为10.05(95%CI：6.34,15.94),阴性似然比为0.11(95%CI：0.08,0.17),诊断比值比为106.00(95%CI：50.89,220.79)。综合受试者工作特征曲线下面积为0.97。结论 NT-proBNP对心源性胸腔积液具有重要的诊断价值。
목적：탐토안기말단B형리납태전체( N-terminal-pro-B-type natriuretic peptide, NT-proBNP)재진단심원성흉강적액중적림상개치。방법검색Pubmed、Embase、중국지망、만방、유보등수거고,수집이용NT-proBNP진단심원성흉강적액문헌병제취수거진행meta분석。결과공유15편문헌1892례연구대상납입본차meta분석,분석결과현시NT-proBNP대심원성흉강적액적종합진단개치분별위：민감도위0.91(95%CI：0.89,0.93),특이도위0.89(95%CI：0.87,0.90),양성사연비위10.05(95%CI：6.34,15.94),음성사연비위0.11(95%CI：0.08,0.17),진단비치비위106.00(95%CI：50.89,220.79)。종합수시자공작특정곡선하면적위0.97。결론 NT-proBNP대심원성흉강적액구유중요적진단개치。
Objective To explore the clinical value of N-terminal-pro-B-type natriuretic peptide ( NT-proBNP) in diagnosis of cardiogenic pleural effusion. Methods Date about NT-proBNP in diagnosis of cardiogenic pleural effusion was retrieved from Pubmed, Embase, CNKI, WanFang Database and VIP Database, and the selected data underwent meta analysis. Results Fifteen documents containing 1892 cases were included in the Meta analysis. The results showed that NT-proBNP value in comprehensive diagnosis of cardiogenic pleural effusion were 0. 91 of sensitivity ( 95% CI:0. 89, 0. 93), 0. 89 of specificity (95% CI:0. 87,0. 90), 10. 05 of positive likelihood ratio (95% CI:6. 34,15. 94), 0. 11 of negative likelihood ratio (95% CI:0. 08,0. 17) and 106. 00 of diagnostic odds ratio (95% CI:50. 89,220. 79). The area under curve of synthetic receiver operator characteristic curve was 0. 97. Conclusion NT-proBNP plays a valu-able role in diagnosis of cardiogenic pleural effusion.