CAJ | 학술논문

目的：探讨组织蛋白酶D( Cath D)、缺氧诱导因子1α( HIF-1α)在宫颈腺癌组织中的表达及其相关性。方法采用免疫组化( EnVisionTM )法分别对2008年3月-2012年2月收治的70例宫颈腺癌组织及其癌旁组织中Cath D、HIF-1α的表达情况进行检测,并分析Cath D、HIF-1α表达的相关性。结果 Cath D 和HIF-1α在宫颈腺癌组织中的阳性表达率均高于癌旁组织(P<0．01)。 Cath D和HIF-1α的表达均与淋巴结转移、远处脏器转移、TNM分期有关,且HIF-1α的表达还与肿瘤直径有关(P<0．05)。 Cath D与HIF-1α在宫颈腺癌组织中表达呈正相关(r=0.51, P<0．01)。结论 Cath D、HIF-1α在宫颈腺癌组织中过表达,其表达水平可间接反应癌组织的转移情况。
목적：탐토조직단백매D( Cath D)、결양유도인자1α( HIF-1α)재궁경선암조직중적표체급기상관성。방법채용면역조화( EnVisionTM )법분별대2008년3월-2012년2월수치적70례궁경선암조직급기암방조직중Cath D、HIF-1α적표체정황진행검측,병분석Cath D、HIF-1α표체적상관성。결과 Cath D 화HIF-1α재궁경선암조직중적양성표체솔균고우암방조직(P<0．01)。 Cath D화HIF-1α적표체균여림파결전이、원처장기전이、TNM분기유관,차HIF-1α적표체환여종류직경유관(P<0．05)。 Cath D여HIF-1α재궁경선암조직중표체정정상관(r=0.51, P<0．01)。결론 Cath D、HIF-1α재궁경선암조직중과표체,기표체수평가간접반응암조직적전이정황。
Objective To investigate the expressions of Cathepsin D ( Cath D) and HIF-1α in cervical adeno-carcinoma tissues and their correlation. Methods The expressions of Cath D and HIF-1α of cervical adenocarcinoma and ambient tissues in 70 patients during March 2008 and February 2012 were detected using immunohistochemisty ( En-VisionTM ) method, and their correlation was also analyzed. Results The positive expression rates of Cath D and HIF-1αin cervical adenocarcinoma tissues were higher than that of ambient tissues (P<0. 01). The expressions of Cath D and HIF-1α were related to lymph node metastasis, distant organ metastasis and TNM staging, and the HIF-1αexpression was related to tumor diameter (P<0. 05). The expressions between Cath D and HIF-1α in cervical adenocarcinoma tissues showed a positive correlation (r=0. 51, P<0. 01). Conclusion Cath D and HIF-1αhave an overexpression in cervi-cal adenocarcinoma tissues, and the expression levels may indirectly reflect the condition of cancer metastasis.