CAJ | 학술논문

目的：评价添加谷氨酰胺营养治疗对食管癌患者营养状况的影响。方法计算机检索1994-2012年中国知网(CNKI)全文期刊数据库、万方数据库、Pubmed数据库、Cochrane Central Register of Controlled Trials(The Co-chrane Library),纳入添加谷氨酰胺营养治疗食管癌患者的随机对照研究,采用RevMan 5.2统计软件进行分析。结果最终纳入的5项研究,包括284例研究对象,其中4项研究属于高质量等级研究。 meta分析结果显示,谷氨酰胺组白蛋白、前白蛋白、IgG水平高于常规营养支持组,C反应蛋白水平低于常规营养支持组(P<0．05),两组IgA与IgM水平比较差异无统计学意义(P>0.05)。结论添加谷氨酰胺营养支持治疗可以明显改善食管癌患者营养不良状况,提高免疫力,减少氧化应激损伤,其效果优于常规营养支持。
목적：평개첨가곡안선알영양치료대식관암환자영양상황적영향。방법계산궤검색1994-2012년중국지망(CNKI)전문기간수거고、만방수거고、Pubmed수거고、Cochrane Central Register of Controlled Trials(The Co-chrane Library),납입첨가곡안선알영양치료식관암환자적수궤대조연구,채용RevMan 5.2통계연건진행분석。결과최종납입적5항연구,포괄284례연구대상,기중4항연구속우고질량등급연구。 meta분석결과현시,곡안선알조백단백、전백단백、IgG수평고우상규영양지지조,C반응단백수평저우상규영양지지조(P<0．05),량조IgA여IgM수평비교차이무통계학의의(P>0.05)。결론첨가곡안선알영양지지치료가이명현개선식관암환자영양불량상황,제고면역력,감소양화응격손상,기효과우우상규영양지지。
Objective To evaluate the influence of Glutamine addition on nutrition status in nutritional therapy of patients with esophagus cancer. Methods Clinical data of Glutamine addition in nutritional therapy of patients with e-sophagus cancer was retrieved from electronic database:CNKI, Wanfang Data,Pubmed and Cochrane Central Register of Controlled Trials (the Cochrane Library) for randomized control trials, and data was analyzed with RevMan 5. 2 software. Results Five study items were recruited including 284 cases and 4 high quality grade studies. Meta analysis results showed that the levels of albumin, prealbumin and IgG were significantly higher, while the C-reactive protein ( CRP) lev-el was significantly lower in Glutamine addition group than those in ordinary nutrition support group (P<0. 05), but the differences in levels of IgA and IgM were not statistically significant (P>0. 05). Conclusion Glutamine addition in nu-tritional therapy of patients with esophagus cancer can significantly improve poor nutritional status, enhance the immunity and reduce damage of the oxidative stress with better effect than that of the ordinary nutrition support.