CAJ | 학술논문

目的：探讨胃间质瘤( gasric stromal tumor, GST)的临床病理因素和预后。方法回顾性分析解放军总医院2005年7月-2013年9月手术治疗的有完整记录103例GST的临床资料。结果103例随访1~84个月,平均27个月,总体1、3、5年生存率分别为95%、89%、80%,中位生存期68个月。单因素分析显示肿瘤部位、是否破裂、Fletcher风险分级、Ki-67指数、是否R0切除和术后是否应用伊马替尼与GST预后相关(P<0．05)；多因素分析显示是否R0切除是影响GST预后的独立危险因素(P<0．05)。结论 GST预后与肿瘤生长部位等多种因素相关,能否R0切除是影响其预后的重要因素。
목적：탐토위간질류( gasric stromal tumor, GST)적림상병리인소화예후。방법회고성분석해방군총의원2005년7월-2013년9월수술치료적유완정기록103례GST적림상자료。결과103례수방1~84개월,평균27개월,총체1、3、5년생존솔분별위95%、89%、80%,중위생존기68개월。단인소분석현시종류부위、시부파렬、Fletcher풍험분급、Ki-67지수、시부R0절제화술후시부응용이마체니여GST예후상관(P<0．05)；다인소분석현시시부R0절제시영향GST예후적독립위험인소(P<0．05)。결론 GST예후여종류생장부위등다충인소상관,능부R0절제시영향기예후적중요인소。
Objective To investigate clinicopathological factors and prognosis of gastric stromal tumors ( GST) . Methods Clinical data of 103 GST patients undergoing surgery during July 2005 and September 2013 in General Hospi-tal of PLA was retrospectively analyzed. Results The 103 patients were followed up for 1-84 months with an average time of 27 months. The total survival rates of one year, three years and five years were 95%, 89% and 80% respectively with a median survival of 68 months. Univariate analysis showed that the prognosis was related to the tumor positions, whether there was rupture or not, Flecture risk classifications, Ki-67 indexes, whether there was R0 resection and appli-cation of Imatinib after operation or not (P<0. 05); multivariate analysis showed that R0 resection was an independent risk factor of prognosis (P<0. 05). Conclusion The prognosis of gastric stromal tumor is related to many clinicopatho-logical factors such as tumor position, and R0 is the most important influence factor of the prognosis.