CAJ | 학술논문

目的：探讨血清C肽与糖化血红蛋白（ HbA1c）联合检测在糖尿病患者临床诊断中的意义与作用。方法选择2011-03～2012-12间于我院就诊的84例糖尿病患者，将其中56例单纯2型糖尿病患者作为糖尿病组，28例糖尿病肾病患者作为糖尿病肾病组，另筛选同期我院体检中心健康成人体检人员30例作为对照组。检测各组HbA1c、空腹血糖（ FBG）、餐后2 h血糖、血清C肽等相关指标并做统计学分析。结果（1）糖尿病组、糖尿病肾病组患者血清HbA1c、FBG、餐后2 h血糖均显著高于对照组，血清C肽水平显著低于对照组（P＜0.05）。（2）糖尿病组与糖尿病肾病组的FBG、餐后2 h血糖水平比较，差异均无统计学意义（P＞0.05）；糖尿病肾病组HbA1c水平显著高于糖尿病组，血清C肽水平显著低于对照组（P＜0.05）。（3）HbA1c与FBG呈正相关（r＝0.443，P＜0.05），与C肽呈负相关（r＝-0.628，P＜0.05）。结论糖尿病患者HbA1c与血清C肽水平发生异常，其结果可以作为反映胰岛素分泌功能和疾病严重程度的指标，两者联合检验对糖尿病肾病辅助诊断有一定价值。
목적：탐토혈청C태여당화혈홍단백（ HbA1c）연합검측재당뇨병환자림상진단중적의의여작용。방법선택2011-03～2012-12간우아원취진적84례당뇨병환자，장기중56례단순2형당뇨병환자작위당뇨병조，28례당뇨병신병환자작위당뇨병신병조，령사선동기아원체검중심건강성인체검인원30례작위대조조。검측각조HbA1c、공복혈당（ FBG）、찬후2 h혈당、혈청C태등상관지표병주통계학분석。결과（1）당뇨병조、당뇨병신병조환자혈청HbA1c、FBG、찬후2 h혈당균현저고우대조조，혈청C태수평현저저우대조조（P＜0.05）。（2）당뇨병조여당뇨병신병조적FBG、찬후2 h혈당수평비교，차이균무통계학의의（P＞0.05）；당뇨병신병조HbA1c수평현저고우당뇨병조，혈청C태수평현저저우대조조（P＜0.05）。（3）HbA1c여FBG정정상관（r＝0.443，P＜0.05），여C태정부상관（r＝-0.628，P＜0.05）。결론당뇨병환자HbA1c여혈청C태수평발생이상，기결과가이작위반영이도소분비공능화질병엄중정도적지표，량자연합검험대당뇨병신병보조진단유일정개치。
Objective To investigate the serum C peptide combined with glycosylated hemoglobin in the diagnosis of diabetes .Methods Selecting 84 patients of diabetes mellitus during March , 2011 and December , 2012 , of which patients with simple type 2 diabetes as DM group, 28 patients with diabetic nephropathy as diabetic nephropathy group , and 30 health adults in the hospital in physical examination personnel examination center during the same period as control group .Detecting HbA1c, fasting blood glucose (FBG), 2h glucose, C pep-tide and other related indicators after meal .Results (1) DM group, diabetic nephropathy group , serum HbA1c, FBG, 2h postprandial blood glucose were significantly higher than those in the control group , and the serum C peptide levels were significantly lower than those in the control group (P<0.05).(2) Diabetic nephropathy group HbA1c was significantly higher than that in DM group , and C peptide levels were significantly lower than those in the control group (P<0.05).(3)The HbA1c was positively correlated with FBG (r=0.443, P<0. 05), and negatively correlated with C peptide (r=-0.628, P<0.05).Conclusion Diabetes in patients with HbA1c and the level of se-rum C peptide are abnormal .The result can reflect the insulin secretion function and disease severity index .The combination of the two tests has a certain value in diagnosis of diabetic nephropathy .