CAJ | 학술논문

目的：研究精神分裂症（以下简称精分症）患者性激素相应变化水平的动态情况。方法选择2011～2013年在我院接受治疗的92例精分症患者作为观察组；另选健康人群92例作为对照组。对两组人群均检测性激素水平，然后对观察组行药物治疗，对比两组患者性激素水平，观察组患者治疗前后性激素水平。结果观察组在促卵泡刺激素（ FSH）和雌二醇（ E2）等指标水平方面均显著低于对照组，促黄体生成素（ LH）和睾酮（ T）等指标水平方面均显著高于对照组。差异均具有统计学意义（均P＜0.05）。观察组在治疗后催乳素（PRL）水平显著高于治疗之前，T水平显著低于治疗前。差异均具有统计学意义（均P＜0.05）。结论精分症患者性腺轴存在功能失调现象，药物治疗会引发性激素非正常分泌，值得临床重视。
목적：연구정신분렬증（이하간칭정분증）환자성격소상응변화수평적동태정황。방법선택2011～2013년재아원접수치료적92례정분증환자작위관찰조；령선건강인군92례작위대조조。대량조인군균검측성격소수평，연후대관찰조행약물치료，대비량조환자성격소수평，관찰조환자치료전후성격소수평。결과관찰조재촉란포자격소（ FSH）화자이순（ E2）등지표수평방면균현저저우대조조，촉황체생성소（ LH）화고동（ T）등지표수평방면균현저고우대조조。차이균구유통계학의의（균P＜0.05）。관찰조재치료후최유소（PRL）수평현저고우치료지전，T수평현저저우치료전。차이균구유통계학의의（균P＜0.05）。결론정분증환자성선축존재공능실조현상，약물치료회인발성격소비정상분비，치득림상중시。
Objective To study sex hormone′s dynamic condition schizophrenias′corresponding change levels .Methods From 2011 to 2013 , a total of 92 patients in the hospital with the disease were treated , which as the observation group , and another 92 cases of healthy people were regarded as the control group .Hormone levels were detected in 2 groups, and sex hormone levels of two groups and the observa-tion group′s sex hormone levels before and after treatment were compared .Results The observation group in indicators of FSH and E 2 levels was significantly lower than the control group .But in indicators of LH and T levels were significantly higher .The differences were statisti-cally significant (P<0.05).The observation group after treatment′s PRL levels was significantly higher than before treatment , but T levels were significantly lower than before treatment .The differences were statistically significant ( P <0.05).Conclusion Patient with schizophrenia′s gonadal axis function has disordered condition .Drug treatment may cause abnormal secretion of hormones .It is worthy of attention.