CAJ | 학술논문

目的：观察当归四逆汤成分组合对心肌缺血再灌注（ MIRI）大鼠血液流变学各指标的影响。方法将32只大鼠分为shame组、I／R组、PPC组、PPC＋L组，建立大鼠MIRI模型，观察各组实验动物血液流变学指标的变化并测量血清 NO含量。结果与shame组比较，I／R组除红细胞沉降率外，其他血液流变学指标均明显升高（P＜0.05）；与I／R组比较，PPC组血液流变学指标均明显下降（P＜0.05）；与 PPC 组比较，PPC＋L组红细胞沉降率升高（ P＜0.05），血液流变学指标的改变与该组大鼠血清NO含量呈反比。结论当归四逆汤成分组合可明显降低血液流变学各指标值，改善大鼠的血液循环，其机制与调节NO的生成及抗炎作用有关。
목적：관찰당귀사역탕성분조합대심기결혈재관주（ MIRI）대서혈액류변학각지표적영향。방법장32지대서분위shame조、I／R조、PPC조、PPC＋L조，건립대서MIRI모형，관찰각조실험동물혈액류변학지표적변화병측량혈청 NO함량。결과여shame조비교，I／R조제홍세포침강솔외，기타혈액류변학지표균명현승고（P＜0.05）；여I／R조비교，PPC조혈액류변학지표균명현하강（P＜0.05）；여 PPC 조비교，PPC＋L조홍세포침강솔승고（ P＜0.05），혈액류변학지표적개변여해조대서혈청NO함량정반비。결론당귀사역탕성분조합가명현강저혈액류변학각지표치，개선대서적혈액순배，기궤제여조절NO적생성급항염작용유관。
Objective To study the effects of GFPC on hemorheology in myocardial ischemia reperfusion injury ( MIRI ) SD rats.Methods 32 SD rats were divided into shame(non-ischemic conditions),I/R(heart subject to ischemia-reperfusion),ppc(heart sub-jected to ischemia-reperfusion treated with GFPC ) ,ppc+L( heart subjected to ischemia-reperfusion treated with GFPC and pre-treated with L-NAME 30 mg/kg,15 min before reperfusion)groups,8 per group.After the model,the left ventricular apical was fixed and then sliced ,hemo-rheology index was recorded by Rheology instrument ,the level of NO was tested by methods of nitrate reduction.Results Compared with those of shame group,except ESR,hemorheology indexes were significantly higher (P<0.05);compared with those of I/R group,hemorheol-ogy indexes of PPC group were significantly decreased ( P<0.05 ); there was the negative interrelationship between NO and hemorheolo-gy.Conclusions GFPC could decrease hemorheology index ,improve microcirculation ,the functional mechanism might be related to regulate the generating and releasing of NO and anti-inflammation.