CAJ | 학술논문

鼻咽癌是中国南方高发的恶性肿瘤，其发病机理目前仍不十分清楚。研究表明，D N A修复功能异常是鼻咽癌发生的可能原因。近年来越来越多的研究显示碱基切除修复（BER）通路中的相关基因的单核苷酸多态性（SNP）是导致DNA修复功能下降的重要原因。BER分为单个核苷酸BER和长片段BER,其中前者是主要的BER修复通路。本文对近年来单个核苷酸BER通路中主要基因SNP与NPC相关的研究进展进行综述。
비인암시중국남방고발적악성종류，기발병궤리목전잉불십분청초。연구표명，D N A수복공능이상시비인암발생적가능원인。근년래월래월다적연구현시감기절제수복（BER）통로중적상관기인적단핵감산다태성（SNP）시도치DNA수복공능하강적중요원인。BER분위단개핵감산BER화장편단BER,기중전자시주요적BER수복통로。본문대근년래단개핵감산BER통로중주요기인SNP여NPC상관적연구진전진행종술。
Nasopharyngeal carcinoma (NPC) is the most common malignant tumor in South China. The mechanism of occurrence of NPC is stil not clear. It was reported that malfunction of repair of DNA damage is linked with the initiation of NPC.In recent years, more and more studies showed that single nucleotide polymorphism(SNP)of relative genes in base excision repair (BER) pathway plays an important role in the impairment of DNA damage repair function. BER pathway is divided into single nucleotide BER and long patch BER, with the former being the major. This paper focus on the progress in the relation of key gene SNPs in BER pathway to initiation of NPC in recent years.