CAJ | 학술논문

以对乙酰氨基环己酮为原料，经Hantzsch反应、水解、拆分、缩合、成盐得抗帕金森氏药物盐酸普拉克索，中间体及终产物结构经红外、氢谱确证，并通过HPLC与终产物标准品对照测得其纯度。新的工艺对各步反应进行了优化，总收率约18.3％，光学纯度99.6％。
이대을선안기배기동위원료，경Hantzsch반응、수해、탁분、축합、성염득항파금삼씨약물염산보랍극색，중간체급종산물결구경홍외、경보학증，병통과HPLC여종산물표준품대조측득기순도。신적공예대각보반응진행료우화，총수솔약18.3％，광학순도99.6％。
Pramipexole Dihydrochloride , an antiparkinson drug , was synthesized by N -( 4 -Oxocyclohexyl ) acetamide via Hantzsch reaction, hydrolysis, isolated, condensation, and salification.The structures of the intermediates and final product were measured by IR , 1 HNMR, and the purity was contrast with standard substance via HPLC.By optimizing each step , the total yield of about 18.3%, with an optical purity of 99.6%.