医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2014年
14期
188-189
,共2页
阿奇霉素%学龄期儿童%下呼吸道感染
阿奇黴素%學齡期兒童%下呼吸道感染
아기매소%학령기인동%하호흡도감염
Azithromycin%School-age Child%LRI
目的：通过本次研究对静注阿奇霉素和红霉素在治疗学龄儿童下呼吸道感染方面的效果和安全性进行探讨。方法：选取在我院接受治疗的114例下呼吸道感染的学龄儿童，借助随机数字表，将所选择的研究对象随机分为试验组和对照组，试验组静脉注射阿奇霉素，对照组静脉注射红霉素。观察两组患者的治疗效果以及不良反应发生情况。结果：试验组总有效率93.1%比对照组总有效率84.2%高，差异有统计学意义（x2=4.89，P<0.05）。试验组细菌阴转率和清除率分别为94.7%和96.4%，高于对照组的68.4%与75.6%，两组差异显著，具有统计学意义（x2=10.22，P<0.05；x2=9.93，P<0.05）。试验组轻微消化道不良反应发生率为12.3%明显低于比对照组的40.4%，从统计学角度差异有意义（x2=11.58，P<0.05）。结论：治疗学龄儿童的下呼吸道感染时注射阿奇霉素效果显著，安全性高。在临床上有重要使用意义。
目的：通過本次研究對靜註阿奇黴素和紅黴素在治療學齡兒童下呼吸道感染方麵的效果和安全性進行探討。方法：選取在我院接受治療的114例下呼吸道感染的學齡兒童，藉助隨機數字錶，將所選擇的研究對象隨機分為試驗組和對照組，試驗組靜脈註射阿奇黴素，對照組靜脈註射紅黴素。觀察兩組患者的治療效果以及不良反應髮生情況。結果：試驗組總有效率93.1%比對照組總有效率84.2%高，差異有統計學意義（x2=4.89，P<0.05）。試驗組細菌陰轉率和清除率分彆為94.7%和96.4%，高于對照組的68.4%與75.6%，兩組差異顯著，具有統計學意義（x2=10.22，P<0.05；x2=9.93，P<0.05）。試驗組輕微消化道不良反應髮生率為12.3%明顯低于比對照組的40.4%，從統計學角度差異有意義（x2=11.58，P<0.05）。結論：治療學齡兒童的下呼吸道感染時註射阿奇黴素效果顯著，安全性高。在臨床上有重要使用意義。
목적：통과본차연구대정주아기매소화홍매소재치료학령인동하호흡도감염방면적효과화안전성진행탐토。방법：선취재아원접수치료적114례하호흡도감염적학령인동，차조수궤수자표，장소선택적연구대상수궤분위시험조화대조조，시험조정맥주사아기매소，대조조정맥주사홍매소。관찰량조환자적치료효과이급불량반응발생정황。결과：시험조총유효솔93.1%비대조조총유효솔84.2%고，차이유통계학의의（x2=4.89，P<0.05）。시험조세균음전솔화청제솔분별위94.7%화96.4%，고우대조조적68.4%여75.6%，량조차이현저，구유통계학의의（x2=10.22，P<0.05；x2=9.93，P<0.05）。시험조경미소화도불량반응발생솔위12.3%명현저우비대조조적40.4%，종통계학각도차이유의의（x2=11.58，P<0.05）。결론：치료학령인동적하호흡도감염시주사아기매소효과현저，안전성고。재림상상유중요사용의의。
Objective:To discuss the effect and safety of intravenous azithromycin and erythromycin in the treatment of children with lower respiratory infection(LRI) through the study.Method:114 school children with LRI in our hospital were selected.114 cases were divided into experimental group and control group randomly with the help of random number table. The experimental group were given intravenous injection of azithromycin while control group were given intravenous injection of erythromycin.Observed therapeutic effects and adverse reactions of two groups.Result:The total effective rate of experimental group was 93.1% higher than that in the control group 84.2%,The difference was statistical y significant(x2=4.89, P<0.05).Bacteria negative conversion rate and clearance rates of experimental group were 94.7% and 96.4%,higher than that of the control group(68.4% and 75.6%).The difference was statistical y significant(x2=10.22,P<0.05;x2=9.93,P<0.05).The incidence of adverse reaction of Mild gastrointestinal adverse in experimental group was 12.3%, significantly lower than that of the control group(40.4%),The difference was statistical y significant(x2=11.58,P<0.05)Conclusion:Injection of azithromycin in the treatment of children with LRI with good effect and safety.It is worth promoting in clinical practice.
