CAJ | 학술논문

目的：建立了液相色谱-串联质谱法快速测定中成药与保健食品中非法添加的11种降脂类化学成分检测方法。采用C18色谱柱，以甲醇-0.1%甲酸溶液（80∶20）为流动相，采用电喷雾电离(ESI)源、多反应监测(MRM)扫描方式，11种成分的检测限满足检测要求。通过与标准谱库中的保留时间和多反应检测的质谱图（MRM）进行对比，快速鉴别样品中违法添加的11种降脂类成分。
목적：건립료액상색보-천련질보법쾌속측정중성약여보건식품중비법첨가적11충강지류화학성분검측방법。채용C18색보주，이갑순-0.1%갑산용액（80∶20）위류동상，채용전분무전리(ESI)원、다반응감측(MRM)소묘방식，11충성분적검측한만족검측요구。통과여표준보고중적보류시간화다반응검측적질보도（MRM）진행대비，쾌속감별양품중위법첨가적11충강지류성분。
To establish a liquid chromatography- tandem mass chromatography (LC-MS/MS) method for the rapid detection of 11 Lipid composition il egal y added in Chinese traditional medicines and health food. A C18 column was used with the mobile phase of 0.1% formic and methanol (20:80). The target compounds were analyzed with LC-MS/MS-ESI. Multiple-reaction monitoring (MRM) was used to screen 11 chemical components in health food and Chinese Traditional Patent Medicine. The LOD of these substances were meet the test requirements. Comparing with retention time and MRM spectrums of reference in library set up by us ,rapid detection of 11 Lipid composition il egal y added in sample.