CAJ | 학술논문

目的：探寻高根治率的耐药HP感染的治疗方案，以减少和避免Hp对抗生素的耐药。方法：收集我院2012.08～2013.08Hp一线方案治疗失败患者78例，随机分为治疗组和对照组，疗程结束4周后行活检组织快速尿素酶检测或复查14C-尿素呼气试验。结果：治疗组根治率为87.50%，对照组根治率为60.53%，治疗组疗效优于对照组，两组比较有显著性差异( P <0.05)。结论：应用埃索美拉唑、左氧氟沙星、阿莫西林联合荆花胃康胶丸的补救方案能提高耐药Hp补救治疗的根治率，可应用于耐药Hp初治失败后的治疗。
목적：탐심고근치솔적내약HP감염적치료방안，이감소화피면Hp대항생소적내약。방법：수집아원2012.08～2013.08Hp일선방안치료실패환자78례，수궤분위치료조화대조조，료정결속4주후행활검조직쾌속뇨소매검측혹복사14C-뇨소호기시험。결과：치료조근치솔위87.50%，대조조근치솔위60.53%，치료조료효우우대조조，량조비교유현저성차이( P <0.05)。결론：응용애색미랍서、좌양불사성、아막서림연합형화위강효환적보구방안능제고내약Hp보구치료적근치솔，가응용우내약Hp초치실패후적치료。
Objective: To explore a high radical treatment rate of Helicobacter pylori (Hp) with drug resistance so as to decrease and avoid Hp resistance to antibiotics. Methods:In our hospital we colected 78 patients which failed to use 1st-line Hp treatment protocol from 08/2012-08/2013 and divided them into two groups by random: Treatment group and Control group. Rapid urease test (RUT) or14C-urea breath test (14C-UBT ) were used to analyze the Hp radical treatment rate after 4 weeks of the treatment. Result:The Hp radical treatment rate of Treatment Group was higher than that of Control Group (87.5% vs 60.53%). There were significant difference between two groups (p<0.05). Conclusion: The remedial fourfold therapy of Esomeprazole, Levofloxacin, Amoxicilin and Jinghuaweikang capsules could increase the radical treatment rate of Hp with drug resistance. This kind of therapy could be used to cure the patients with drug resistance Hp after the failure of 1st-line therapy of Hp eradication.