中华器官移植杂志
中華器官移植雜誌
중화기관이식잡지
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
2013年
5期
265-268
,共4页
肾移植%基因%移植物排斥
腎移植%基因%移植物排斥
신이식%기인%이식물배척
Kidney transplantation%Genes%Graft rejection
目的 评价肾移植供、受者间自然杀伤细胞免疫球蛋白样受体(KIR)基因、KIR配体HLA-C基因和KIR配体HLA-Bw4I80相关基因的实际错配概率及其对受者急性排斥反应(AR)的影响.方法 对322例肾移植受者以及相应的196例尸体肾移植供者的KIR基因、KIR配体HLA-C基因、KIR配体HLA-Bw4I80相关基因的错配概率进行分析,同时研究KIR配体HLA-Bw4I80相关基因错配与AR发生率及AR逆转率的关系.结果 322例受者与相应供者间KIR-L基因平均错配概率为4.73％,KIR-S基因平均错配概率为9.10％,KIR配体HLA-C基因平均错配概率为1.95％.322例受者中,与相应供者KIR配体HLA-Bw4I80相关基因发生错配的有245例(76.09％),无错配的有77例(23.91％).245例KIR配体HLA-Bw4I80相关基因错配组的AR发生率为8.16％,77例无错配组的AR发生率7.79％(P＞0.05)；错配组AR逆转率为95.0％,无错配组AR逆转率为66.7％(P＞0.05).结论 肾移植供、受者间KIR配体HLA-Bw4I80相关基因错配概率较高,其错配对AR逆转的影响尚需进一步大样本研究来验证.
目的 評價腎移植供、受者間自然殺傷細胞免疫毬蛋白樣受體(KIR)基因、KIR配體HLA-C基因和KIR配體HLA-Bw4I80相關基因的實際錯配概率及其對受者急性排斥反應(AR)的影響.方法 對322例腎移植受者以及相應的196例尸體腎移植供者的KIR基因、KIR配體HLA-C基因、KIR配體HLA-Bw4I80相關基因的錯配概率進行分析,同時研究KIR配體HLA-Bw4I80相關基因錯配與AR髮生率及AR逆轉率的關繫.結果 322例受者與相應供者間KIR-L基因平均錯配概率為4.73％,KIR-S基因平均錯配概率為9.10％,KIR配體HLA-C基因平均錯配概率為1.95％.322例受者中,與相應供者KIR配體HLA-Bw4I80相關基因髮生錯配的有245例(76.09％),無錯配的有77例(23.91％).245例KIR配體HLA-Bw4I80相關基因錯配組的AR髮生率為8.16％,77例無錯配組的AR髮生率7.79％(P＞0.05)；錯配組AR逆轉率為95.0％,無錯配組AR逆轉率為66.7％(P＞0.05).結論 腎移植供、受者間KIR配體HLA-Bw4I80相關基因錯配概率較高,其錯配對AR逆轉的影響尚需進一步大樣本研究來驗證.
목적 평개신이식공、수자간자연살상세포면역구단백양수체(KIR)기인、KIR배체HLA-C기인화KIR배체HLA-Bw4I80상관기인적실제착배개솔급기대수자급성배척반응(AR)적영향.방법 대322례신이식수자이급상응적196례시체신이식공자적KIR기인、KIR배체HLA-C기인、KIR배체HLA-Bw4I80상관기인적착배개솔진행분석,동시연구KIR배체HLA-Bw4I80상관기인착배여AR발생솔급AR역전솔적관계.결과 322례수자여상응공자간KIR-L기인평균착배개솔위4.73％,KIR-S기인평균착배개솔위9.10％,KIR배체HLA-C기인평균착배개솔위1.95％.322례수자중,여상응공자KIR배체HLA-Bw4I80상관기인발생착배적유245례(76.09％),무착배적유77례(23.91％).245례KIR배체HLA-Bw4I80상관기인착배조적AR발생솔위8.16％,77례무착배조적AR발생솔7.79％(P＞0.05)；착배조AR역전솔위95.0％,무착배조AR역전솔위66.7％(P＞0.05).결론 신이식공、수자간KIR배체HLA-Bw4I80상관기인착배개솔교고,기착배대AR역전적영향상수진일보대양본연구래험증.
Objective To evaluate the actual mismatch risk for KIR genes,KIR ligand HLA-C gene and KIR ligand HLA-Bw4I80 related genes in kidney transplant recipients and their donors.Method KIR genes,KIR ligand HLA-C gene and KIR ligand HLA-Bw4I80 related genes were analyzed in 322 recipients and their donors who received kidney transplantation.The effect of mismatches on acute rejection after transplantation was studied as well.Result In 322 cases of recipients and their donors,average mismatch risk for KIR-L gene was 4.73％,9.10％ for KIR-S gene and 1.95％ for KIR ligand HLA-C gene respectively.There were 245 cases (76.09％) of KIR ligand HLA-Bw4I80 related genes mismatch and 77 cases (23.91 ％) of match resepctively.There was no statistically significant difference in AR rate between KIR ligand HLA-Bw4I80 related genes mismatch group and match group (8.16％ in 245 vs.7.79％ in 77) (P＞0.05).AR reversal rate in mismatch group and match group was 95.0％ and 66.7％ (P＞0.05).Conclusion The mismatch risk for KIR ligand HLA-Bw4I80 related genes was even common between kidney transplant recipients and their donors,and this specific mismatch may be of benefit to patients who undergo actuate rejection.Further study is still required.
