CAJ | 학술논문

精神分裂症是一种常见的多因子参与的复杂疾病，司法精神病学鉴定中对精神分裂症的涉及甚多，但无有效的生物学鉴定指标。研究表明，多巴胺神经递质功能紊乱可能在精神分裂症的发生及其主要症状中发挥重要作用。本文综述了多巴胺受体的分类、基因结构以及近年来关于多巴胺受体基因遗传多态性与精神分裂症的关联研究及其法医学意义。
정신분렬증시일충상견적다인자삼여적복잡질병，사법정신병학감정중대정신분렬증적섭급심다，단무유효적생물학감정지표。연구표명，다파알신경체질공능문란가능재정신분렬증적발생급기주요증상중발휘중요작용。본문종술료다파알수체적분류、기인결구이급근년래관우다파알수체기인유전다태성여정신분렬증적관련연구급기법의학의의。
Schizophrenia is a common but complex mental disorder affected by multiple factors. Forensic psychiatric assessment of schizophrenia involves evaluations on many aspects, but there is no effective biological identification index for schizophrenia. Researches indicate that dysfunction of dopaminergic neurotransmission plays an important role in the pathogenesis of schizophrenia. Our study reviews the classification, genetic structure of dopamine receptors and the recent pertinent studies between the dopamine receptors and schizophrenia and its forensic significance.