CAJ | 학술논문

精神分裂症患者的暴力攻击行为发生率高于一般人群，暴力攻击行为在某些方面具有显著的遗传倾向性，与精神分裂症患者暴力攻击行为研究最多的是儿茶酚氧位甲基转移酶（catechol-O-methyltrans-ferase ， COMT ）基因。本文从COMT Val158Met 和COMT Ala72Ser 的SNP 多态性、COMT 基因单倍型、COMT基因启动子区DNA甲基化等方面对COMT基因变异与精神分裂症患者暴力攻击行为的相关性研究进行综述，并提出精神分裂症患者暴力攻击行为的遗传学研究方向。
정신분렬증환자적폭력공격행위발생솔고우일반인군，폭력공격행위재모사방면구유현저적유전경향성，여정신분렬증환자폭력공격행위연구최다적시인다분양위갑기전이매（catechol-O-methyltrans-ferase ， COMT ）기인。본문종COMT Val158Met 화COMT Ala72Ser 적SNP 다태성、COMT 기인단배형、COMT기인계동자구DNA갑기화등방면대COMT기인변이여정신분렬증환자폭력공격행위적상관성연구진행종술，병제출정신분렬증환자폭력공격행위적유전학연구방향。
The prevalence of violence behavior in patients with schizophrenia is higher than that in common population. Data suggest that genetic factors may play a substantial role for the etiology of the behavior. Among the particular gene polymorphisms that have been considered to be involved in vio-lence behavior, the catechol-O-methyltransferase (COMT) gene had been the focus of recent research. This article reviews the association research between COMT gene and violence behavior in patients with schizophrenia in several aspects: SNP polymorphism of COMT Val158Met and COMT Ala72Ser, haplo-type of COMT gene and DNA methylation of promoter region of COMT gene. The genetic research di-rection is presented for patients with schizophrenia.