白求恩医学杂志
白求恩醫學雜誌
백구은의학잡지
Journal of Bethune Military Medical College
2014年
3期
238-239
,共2页
新生儿%肺表面活性物质%胎粪吸入综合征%临床疗效
新生兒%肺錶麵活性物質%胎糞吸入綜閤徵%臨床療效
신생인%폐표면활성물질%태분흡입종합정%림상료효
Neonatal%Pulmonary surfactant%Meconium aspiration syndrome%Clinical efficacy
目的：探讨肺表面活性物质（pulmonary surfactant，PS）治疗新生儿胎粪吸入综合征（meconium aspiration syn-drome，MAS）的临床效果。方法选择MAS患儿84例，随机分为两组，各42例。对照组予以机械通气和常规治疗，观察组在此基础上加用PS治疗，对比两组临床治疗效果。结果观察组患儿治愈率为95．24％，高于对照组的80．95％（ P ＜0．05）；观察组住院时间为（12．09±3．11）d，短于对照组的（17．81±4．07）d （ P ＜0．01）。两组治疗前动脉二氧化碳分压（PaCO2）和动脉氧分压（PaO2）差异均无统计学意义（ P ＞0．05）；治疗24 h后，观察组PaCO2低于对照组（ P ＜0．01），PaO2高于对照组（ P＜0．01）。结论机械通气联合PS治疗新生儿MAS临床效果明显，有利于改善血气情况。
目的：探討肺錶麵活性物質（pulmonary surfactant，PS）治療新生兒胎糞吸入綜閤徵（meconium aspiration syn-drome，MAS）的臨床效果。方法選擇MAS患兒84例，隨機分為兩組，各42例。對照組予以機械通氣和常規治療，觀察組在此基礎上加用PS治療，對比兩組臨床治療效果。結果觀察組患兒治愈率為95．24％，高于對照組的80．95％（ P ＜0．05）；觀察組住院時間為（12．09±3．11）d，短于對照組的（17．81±4．07）d （ P ＜0．01）。兩組治療前動脈二氧化碳分壓（PaCO2）和動脈氧分壓（PaO2）差異均無統計學意義（ P ＞0．05）；治療24 h後，觀察組PaCO2低于對照組（ P ＜0．01），PaO2高于對照組（ P＜0．01）。結論機械通氣聯閤PS治療新生兒MAS臨床效果明顯，有利于改善血氣情況。
목적：탐토폐표면활성물질（pulmonary surfactant，PS）치료신생인태분흡입종합정（meconium aspiration syn-drome，MAS）적림상효과。방법선택MAS환인84례，수궤분위량조，각42례。대조조여이궤계통기화상규치료，관찰조재차기출상가용PS치료，대비량조림상치료효과。결과관찰조환인치유솔위95．24％，고우대조조적80．95％（ P ＜0．05）；관찰조주원시간위（12．09±3．11）d，단우대조조적（17．81±4．07）d （ P ＜0．01）。량조치료전동맥이양화탄분압（PaCO2）화동맥양분압（PaO2）차이균무통계학의의（ P ＞0．05）；치료24 h후，관찰조PaCO2저우대조조（ P ＜0．01），PaO2고우대조조（ P＜0．01）。결론궤계통기연합PS치료신생인MAS림상효과명현，유리우개선혈기정황。
Objective To explore the clinical effect of pulmonary surfactant ( PS) on the treatment of meconium aspiration syn-drome(MAS).Methods Eighty-four children with MAS were randomly divided into two groups ( n =42,each).The control group was treated with mechanical ventilation and conventional therapy ,based on which ,the observation group was given additional pulmonary surfactant.Then,therapeutic effect of the two groups was compared .Results In the observation group,the cure rate was 95.24%, higher than 80.95%of control group( P <0.05)and the hospitalization time was(12.09 ±3.11)d, shorter than(17.81 ±4.07)d of control group( P <0.01).There was no significant difference between carbon dioxide partial pressures ( P >0.05),however 24 h after treatment,the carbon dioxide partial pressure of observation group was lower than that of the control group ( P <0.01)but oxygen par-tial pressure was higher ( P <0.01).Conclusion The treatment of mechanical ventilation combined with pulmonary surfactant is ob -viously effective to neonates with MAS and can improve blood gas of the patients .
