CAJ | 학술논문

目的：探讨血浆N-末端脑钠肽前体（NT-proBNP）及肌钙蛋白I（cTnI）含量改变在慢性心力衰竭（CHF）患者中的临床意义。方法选择CHF患者194例，根据美国纽约心功能分级分为心功能I级～IV级4组，分别检测血浆NT-proBNP、cTnI及肾功能（肌酐），并与健康对照组进行比较。结果 CHF各组血浆NT-proBNP水平均高于健康对照组（ P ＜0．05）；心功能II、III、IV级组血浆cTnI水平均高于健康对照组（ P ＜0．05），且随心力衰竭程度的加重，血浆NT-proBNP和cTnI水平逐渐增高。结论血浆NT-proBNP及cTnI水平均随心力衰竭程度的加重而增高，两者均对CHF诊断具有重要意义。
목적：탐토혈장N-말단뇌납태전체（NT-proBNP）급기개단백I（cTnI）함량개변재만성심력쇠갈（CHF）환자중적림상의의。방법선택CHF환자194례，근거미국뉴약심공능분급분위심공능I급～IV급4조，분별검측혈장NT-proBNP、cTnI급신공능（기항），병여건강대조조진행비교。결과 CHF각조혈장NT-proBNP수평균고우건강대조조（ P ＜0．05）；심공능II、III、IV급조혈장cTnI수평균고우건강대조조（ P ＜0．05），차수심력쇠갈정도적가중，혈장NT-proBNP화cTnI수평축점증고。결론혈장NT-proBNP급cTnI수평균수심력쇠갈정도적가중이증고，량자균대CHF진단구유중요의의。
Objective To investigate the changes and clinical significance of the level of the plasma NT -proBNP and cTnI in patients with chronic heart failure ( CHF) .Methods One hundred and ninety-four patients with CHF were selected and divided into cardial funtion I~IV groups in accordance with NYHA .NT-proBNP,cTnI and Cr were measured and compared with that of healthy con-trol group.Results The levels of the plasma NT-proBNP and cTnI in CHF group were higher than those of the healthy control group (P <0.05) and the levels of cTnI of group II ,III and IV were higher than those of the healthy control group ( P <0.05),and the lev-els of NT-proBNP and cTnI increased with aggravation of heart failure .Conclusion Both the levels of the plasma NT-proBNP and cTnI increased with aggravation of heart failure are of important diagnosis value to the patients with CHF .