CAJ | 학술논문

目的：探讨四联疗法治疗小儿消化性溃疡的临床效果及安全性。方法将90例小儿消化性溃疡患者随机分为两组，各45例。对照组患儿采用奥美拉唑＋阿莫西林＋克拉霉素三联疗法治疗；观察组患儿采用铋剂＋奥美拉唑＋阿莫西林＋呋喃唑酮四联疗法治疗。观察两组临床效果及不良反应情况。结果90例患儿均完成治疗疗程，未因不良反应而终止治疗。观察组总有效率为95．56％，高于对照组的82．22％（ P ＜0．05）；观察组幽门螺杆菌（ Hp ）根除率为93．33％，高于对照组的73．33％（ P ＜0．05）；观察组不良反应发生率低于对照组（ P ＜0．05）。结论采用四联疗法治疗小儿消化性溃疡，能有效根除Hp，提高治疗效果，且不良反应少。
목적：탐토사련요법치료소인소화성궤양적림상효과급안전성。방법장90례소인소화성궤양환자수궤분위량조，각45례。대조조환인채용오미랍서＋아막서림＋극랍매소삼련요법치료；관찰조환인채용필제＋오미랍서＋아막서림＋부남서동사련요법치료。관찰량조림상효과급불량반응정황。결과90례환인균완성치료료정，미인불량반응이종지치료。관찰조총유효솔위95．56％，고우대조조적82．22％（ P ＜0．05）；관찰조유문라간균（ Hp ）근제솔위93．33％，고우대조조적73．33％（ P ＜0．05）；관찰조불량반응발생솔저우대조조（ P ＜0．05）。결론채용사련요법치료소인소화성궤양，능유효근제Hp，제고치료효과，차불량반응소。
Objective To study the efficacy and safety of bismuth ,omeprazole, amoxicillin,furazolidone quadruple therapy in the treatment of peptic ulcer in children .Methods Ninety cases of peptic ulcer patients chosen as the research objects were randomly divided into two groups ( n =45,each).The control group was given omeprazole ,amoxicillin,and clarithromycin therapy .The observa-tion group was treated with omeprazole,amoxicillin,bismuth,and furazolidone treatment.The curative effect and safety of two groups were observed .Results Ninety patients completed the treatment course and did not terminate the treatment because of adverse reac -tions.The total cure rate of the observation group was 95.56%, higher than82.22%of the control group( P <0.05).Helicobacter pylori(Hp) eradication rate (93.33%) was higher than that of the control group (73.33%, P <0.05).The adverse reaction rate of observation group was lower than that of the control group ( P <0.05).Conclusion Bismuth,omeprazole,amoxicillin,furazolidone quadruple therapy in treatment of peptic ulcer can effectively eradicate Hp with better curative effect and less adverse reactions .