CAJ | 학술논문

以脯氨酸为原料在液相中合成了脯氨酰脯氨酸二肽（Pro-Pro ）．通过正交试验对实验条件进行优化，确定了肽键形成的最佳温度为30℃、时间为20 h、投料摩尔比为1∶1．2、催化剂为N-羟基苯并三氮唑（HOBT ）、溶剂为二氯甲烷（DCM ），产率达78％．产物经红外光谱（IR）和核磁共振氢谱（1 H NMR）进行结构表征，通过熔点测定和热重（TG）测试考察产物热性能．结果表明：IR中产物的C＝ O和C -N伸缩振动吸收峰分别出现在1689 cm -1和1397 cm -1处，均向高波数移动，说明产物中吡咯环具有较大张力；T G检测表明脯氨酰脯氨酸二肽的最高使用温度为155℃．
이포안산위원료재액상중합성료포안선포안산이태（Pro-Pro ）．통과정교시험대실험조건진행우화，학정료태건형성적최가온도위30℃、시간위20 h、투료마이비위1∶1．2、최화제위N-간기분병삼담서（HOBT ）、용제위이록갑완（DCM ），산솔체78％．산물경홍외광보（IR）화핵자공진경보（1 H NMR）진행결구표정，통과용점측정화열중（TG）측시고찰산물열성능．결과표명：IR중산물적C＝ O화C -N신축진동흡수봉분별출현재1689 cm -1화1397 cm -1처，균향고파수이동，설명산물중필각배구유교대장력；T G검측표명포안선포안산이태적최고사용온도위155℃．
Pro-Pro was synthesized in solution phase with proline as the starting material .The experimental condition was optimized by orthogonal test in this paper .The maximum yield 78% was obtained when reaction temperature was 30 ℃ ,time was 20 h ,mole ratio was 1∶1 .2 with HOBT as catalyzer and DCM as solvent .The structure of products was charac-terized by IR Spectrum and 1 H NMR ,the thermal properties was analyzed by melting point and TG .Results showed :Pro-Pro as tertiary amides ,C= O and C -N stretching vibration absorption peak move to high wave number 1 689 cm -1 and 1 397 cm -1 ,which indicated pyr-role rings in proline has larger tension and strengthen bond vibration .The maximum service temperature of Pro-Pro was 155 ℃ indicated by TG test .