实用临床医学
實用臨床醫學
실용림상의학
Practical Clinical Medicine
2014年
4期
80-82
,共3页
轮状病毒性肠炎%轮状病毒感染%心肌酶谱%肝功能%心肌损伤%肝损伤%小儿
輪狀病毒性腸炎%輪狀病毒感染%心肌酶譜%肝功能%心肌損傷%肝損傷%小兒
륜상병독성장염%륜상병독감염%심기매보%간공능%심기손상%간손상%소인
rotavirus enteritis%rotavirus infection%myocardial enzyme spectrum%liver function%myocardial injury%liver injury%children
目的:探讨轮状病毒对小儿肝脏和心肌造成的不良影响。方法使用全自动生化分析仪、采用酶联免疫吸附法检测60例轮状病毒性肠炎患儿(观察组)和60例大便细菌培养与轮状病毒检测结果均为阴性的腹泻患儿(对照组)血清肝功能[谷丙转氨酶(ALT)、谷草转氨酶(AST)]和心肌酶谱[肌酸激酶同工酶(CK-MB)、肌酸激酶(CK)和乳酸脱氢酶(LDH)]的水平,并观察2组肝脏、心肌损伤发生率的情况。结果观察组血清LDH(262.39±92.47)U·L-1、CK-MB(49.99±33.87)U·L-1、CK(197.52±82.36)U·L-1、AST(38.20±23.98)U·L-1和ALT(40.24±24.89)U·L-1水平,均明显高于对照组的(193.33±76.58)U·L-1、(22.53±20.67)U·L-1、(139.99±70.87)U·L-1、(25.31±16.59)U·L-1和(24.33±18.64)U·L-1(均P<0.05);观察组肝脏、心肌损伤发生率分别为31.7%、51.7%,均明显高于对照组的16.7%、18.3%(均P<0.05)。结论小儿轮状病毒性肠炎常合并肝脏、心肌损害,应尽早对轮状病毒性肠炎患儿进行肝功能及心肌酶的检测,以便临床及早对轮状病毒性肠炎患儿进行干预治疗。
目的:探討輪狀病毒對小兒肝髒和心肌造成的不良影響。方法使用全自動生化分析儀、採用酶聯免疫吸附法檢測60例輪狀病毒性腸炎患兒(觀察組)和60例大便細菌培養與輪狀病毒檢測結果均為陰性的腹瀉患兒(對照組)血清肝功能[穀丙轉氨酶(ALT)、穀草轉氨酶(AST)]和心肌酶譜[肌痠激酶同工酶(CK-MB)、肌痠激酶(CK)和乳痠脫氫酶(LDH)]的水平,併觀察2組肝髒、心肌損傷髮生率的情況。結果觀察組血清LDH(262.39±92.47)U·L-1、CK-MB(49.99±33.87)U·L-1、CK(197.52±82.36)U·L-1、AST(38.20±23.98)U·L-1和ALT(40.24±24.89)U·L-1水平,均明顯高于對照組的(193.33±76.58)U·L-1、(22.53±20.67)U·L-1、(139.99±70.87)U·L-1、(25.31±16.59)U·L-1和(24.33±18.64)U·L-1(均P<0.05);觀察組肝髒、心肌損傷髮生率分彆為31.7%、51.7%,均明顯高于對照組的16.7%、18.3%(均P<0.05)。結論小兒輪狀病毒性腸炎常閤併肝髒、心肌損害,應儘早對輪狀病毒性腸炎患兒進行肝功能及心肌酶的檢測,以便臨床及早對輪狀病毒性腸炎患兒進行榦預治療。
목적:탐토륜상병독대소인간장화심기조성적불량영향。방법사용전자동생화분석의、채용매련면역흡부법검측60례륜상병독성장염환인(관찰조)화60례대편세균배양여륜상병독검측결과균위음성적복사환인(대조조)혈청간공능[곡병전안매(ALT)、곡초전안매(AST)]화심기매보[기산격매동공매(CK-MB)、기산격매(CK)화유산탈경매(LDH)]적수평,병관찰2조간장、심기손상발생솔적정황。결과관찰조혈청LDH(262.39±92.47)U·L-1、CK-MB(49.99±33.87)U·L-1、CK(197.52±82.36)U·L-1、AST(38.20±23.98)U·L-1화ALT(40.24±24.89)U·L-1수평,균명현고우대조조적(193.33±76.58)U·L-1、(22.53±20.67)U·L-1、(139.99±70.87)U·L-1、(25.31±16.59)U·L-1화(24.33±18.64)U·L-1(균P<0.05);관찰조간장、심기손상발생솔분별위31.7%、51.7%,균명현고우대조조적16.7%、18.3%(균P<0.05)。결론소인륜상병독성장염상합병간장、심기손해,응진조대륜상병독성장염환인진행간공능급심기매적검측,이편림상급조대륜상병독성장염환인진행간예치료。
Objective To study the adverse effects of rotavirus on the liver and myocardium in children.Methods The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST), cre-atine kinase isoenzyme (CK-MB),creatine kinase(CK)and lactate dehydrogenase(LDH)were measured by ELISA using automatic biochemical analyzer in 60 children with rotavirus enteritis (observation group) and 60 children with negative bacterial stool culture and rotavirus detection results (control group).Moreover, the incidences of hepatic and myocardial injury were observed in both groups. Results The levels of serum LDH,CK-MB, CK, AST and ALT in observation group[(262.39±92.47)U· L -1, (49.99 ±33.87)U·L -1, (197.52 ±82.36)U·L -1, (38.20 ±23.98)U·L -1 and (40.24 ±24.89)U·L -1, respectively] were significantly higher than those in control group [(193.33±76.58)U·L-1,(22.53±20.67) U·L-1, (139.99 ±70.87)U·L-1, (25.31 ±16.59)U·L-1 and (24.33 ±18.64)U·L-1,respectively] (P<0.05).In addition, the incidences of hepatic and myocardial injury in observation group (31.7% and 51.7%, respectively) were significantly higher than those in control group(16.7% and 18.3%, respectively)(P<0.05). Conclusion Rotavirus enteritis is often associated with hepatic and myocardial injury in children. Therefore, liver function and myocardial enzymes should be determined and intervention treatment should be performed as soon as possible in children with rotavirus enteritis.