实用临床医学
實用臨床醫學
실용림상의학
Practical Clinical Medicine
2014年
4期
26-27,30
,共3页
孕妇%叶酸%维生素B12%铁蛋白质
孕婦%葉痠%維生素B12%鐵蛋白質
잉부%협산%유생소B12%철단백질
pregnant women%folic acid%vitamin B12%ferritin
目的：探讨早、中期妊娠妇女血清叶酸、维生素B12及铁蛋白的含量水平。方法将新疆察布查尔县800例进行产前检查的孕妇按孕期的不同分为2组：早孕组（220例）和中孕组（580例）。选择同期体检的非妊娠健康妇女800例为对照组。对各组研究对象空腹血清中的叶酸、维生素B12和铁蛋白的含量进行测定，并对各数据进行统计分析。结果早孕组叶酸、维生素B12和铁蛋白含量与对照组比较差异均无统计学意义（均P＞0.05）；中孕组叶酸、维生素B12和铁蛋白含量均明显低于对照组[（7.9±30.2） ng·mL-1、（432.1±48.3） pg·mL-1和（58.5±39.6）ng·mL-1比（9.2±35.1）ng· mL-1、（598.5±60.9） pg·mL-1和（101.7±49.7）ng·mL-1，均P＜0.05]。孕妇分娩前红细胞内叶酸、维生素B12和铁蛋白与新生儿体质量无显著的相关性（r=0.021、0.016、0.037，均P＞0.05）。结论中期妊娠孕妇血清中的叶酸、维生素B12和铁蛋白的含量明显降低，及早采取补充或干预性治疗，对减少或杜绝缺陷新生儿的出生率、提高优生优育有极其重要的意义。
目的：探討早、中期妊娠婦女血清葉痠、維生素B12及鐵蛋白的含量水平。方法將新疆察佈查爾縣800例進行產前檢查的孕婦按孕期的不同分為2組：早孕組（220例）和中孕組（580例）。選擇同期體檢的非妊娠健康婦女800例為對照組。對各組研究對象空腹血清中的葉痠、維生素B12和鐵蛋白的含量進行測定，併對各數據進行統計分析。結果早孕組葉痠、維生素B12和鐵蛋白含量與對照組比較差異均無統計學意義（均P＞0.05）；中孕組葉痠、維生素B12和鐵蛋白含量均明顯低于對照組[（7.9±30.2） ng·mL-1、（432.1±48.3） pg·mL-1和（58.5±39.6）ng·mL-1比（9.2±35.1）ng· mL-1、（598.5±60.9） pg·mL-1和（101.7±49.7）ng·mL-1，均P＜0.05]。孕婦分娩前紅細胞內葉痠、維生素B12和鐵蛋白與新生兒體質量無顯著的相關性（r=0.021、0.016、0.037，均P＞0.05）。結論中期妊娠孕婦血清中的葉痠、維生素B12和鐵蛋白的含量明顯降低，及早採取補充或榦預性治療，對減少或杜絕缺陷新生兒的齣生率、提高優生優育有極其重要的意義。
목적：탐토조、중기임신부녀혈청협산、유생소B12급철단백적함량수평。방법장신강찰포사이현800례진행산전검사적잉부안잉기적불동분위2조：조잉조（220례）화중잉조（580례）。선택동기체검적비임신건강부녀800례위대조조。대각조연구대상공복혈청중적협산、유생소B12화철단백적함량진행측정，병대각수거진행통계분석。결과조잉조협산、유생소B12화철단백함량여대조조비교차이균무통계학의의（균P＞0.05）；중잉조협산、유생소B12화철단백함량균명현저우대조조[（7.9±30.2） ng·mL-1、（432.1±48.3） pg·mL-1화（58.5±39.6）ng·mL-1비（9.2±35.1）ng· mL-1、（598.5±60.9） pg·mL-1화（101.7±49.7）ng·mL-1，균P＜0.05]。잉부분면전홍세포내협산、유생소B12화철단백여신생인체질량무현저적상관성（r=0.021、0.016、0.037，균P＞0.05）。결론중기임신잉부혈청중적협산、유생소B12화철단백적함량명현강저，급조채취보충혹간예성치료，대감소혹두절결함신생인적출생솔、제고우생우육유겁기중요적의의。
Objective To investigate the serum levels of folic acid,vitamin B12 and ferritin in early and mid-pregnant women. Methods A total of 800 pregnant women undergoing prenatal examination in Maternal and Child Health Care Hospital of Chabuzha ’er County of Xinjiang Uygur Autonomous Region were divided into early pregnant group (n=220) and mid-pregnant group (n=580).In addition, 800 healthy non-pregnant women were selected as the control group.The fasting serum folic acid, vitamin B12 and ferritin levels were determined and the data obtained were statistically analyzed. Results There were no significant differences in levels of serum folic acid,vitamin B12 and ferritin between early pregnant group and control group(P>0.05).However,serum levels of folic acid, vitamin B12 and ferritin in mid-pregnant group were significantly lower than those in control group [(7.9±30.2)ng· mL-1,(432.1±48.3)pg·mL-1 and (58.5±39.6)ng·mL-1 vs (9.2±35.1)ng·mL-1,(598.5±60.9)pg·mL-1 and (101.7±49.7)ng·mL-1,respectively; P<0.05]. Levels of folic acid,vitamin B12 and ferritin in erythrocytes before delivery were not correlated with neonatal weight(r=0.021,0.016 and 0.037,respectively;P>0.05). Conclusion Serum levels of folic acid, vitamin B12 and ferritin decreased obviously in mid-pregnant women. Therefore, the supplement or intervention treatment should be performed as soon as possible for reducing or eliminating birth defects and improving prenatal and postnatal care.
