实用临床医学
實用臨床醫學
실용림상의학
Practical Clinical Medicine
2014年
4期
8-9,13
,共3页
肖成伟%杨在东%张小芹%陈源浩
肖成偉%楊在東%張小芹%陳源浩
초성위%양재동%장소근%진원호
乌司他丁%婴幼儿%脓毒性休克%白介素-1%肿瘤坏死因子α%降钙素
烏司他丁%嬰幼兒%膿毒性休剋%白介素-1%腫瘤壞死因子α%降鈣素
오사타정%영유인%농독성휴극%백개소-1%종류배사인자α%강개소
ulinastatin%infants%septic shock%interleukin-1%tumor necrosis factor-α%procalcitonin
目的:探讨乌司他丁对脓毒性休克婴幼儿白介素-1(IL-1)、肿瘤坏死因子α(TNF-α)及降钙素原(PCT)的影响。方法将60例脓毒性休克患儿按随机数字表法分为对照组和治疗组,每组30例。对照组给予抗休克和病因治疗,治疗组在对照组治疗的基础上,给予乌司他丁2万 U·kg-1加入5%葡萄糖注射液50 mL中静脉滴注,q8h。2组均5 d 为1个疗程。2组患儿分别于入住ICU时及治疗5 d 后采集静脉血4 mL,测定TNF-α、IL-1及PCT,观察治疗前后TNF-α、IL-1及PCT水平的变化。结果2组治疗前IL-1、TNF-α和PCT水平的变化比较差异均无统计学意义(均 P>0.05);治疗组治疗5 d 后 IL-1、TNF-α和 PCT 分别为(86.48±17.29)pg·L-1、(105.86±20.79)pg·L-1和(5.33±0.85)ng·mL-1,对照组治疗5 d 后IL-1、TNF-α和PCT分别为(112.34±18.54)pg·L-1、(189.04±28.36)pg·L-1和(8.54±1.43)ng·mL-1,治疗组明显低于对照组(均P<0.05)。结论乌司他丁对脓毒性休克婴幼儿IL-1、TNF-α及PCT有明显降低作用,从而能改善患儿的预后。
目的:探討烏司他丁對膿毒性休剋嬰幼兒白介素-1(IL-1)、腫瘤壞死因子α(TNF-α)及降鈣素原(PCT)的影響。方法將60例膿毒性休剋患兒按隨機數字錶法分為對照組和治療組,每組30例。對照組給予抗休剋和病因治療,治療組在對照組治療的基礎上,給予烏司他丁2萬 U·kg-1加入5%葡萄糖註射液50 mL中靜脈滴註,q8h。2組均5 d 為1箇療程。2組患兒分彆于入住ICU時及治療5 d 後採集靜脈血4 mL,測定TNF-α、IL-1及PCT,觀察治療前後TNF-α、IL-1及PCT水平的變化。結果2組治療前IL-1、TNF-α和PCT水平的變化比較差異均無統計學意義(均 P>0.05);治療組治療5 d 後 IL-1、TNF-α和 PCT 分彆為(86.48±17.29)pg·L-1、(105.86±20.79)pg·L-1和(5.33±0.85)ng·mL-1,對照組治療5 d 後IL-1、TNF-α和PCT分彆為(112.34±18.54)pg·L-1、(189.04±28.36)pg·L-1和(8.54±1.43)ng·mL-1,治療組明顯低于對照組(均P<0.05)。結論烏司他丁對膿毒性休剋嬰幼兒IL-1、TNF-α及PCT有明顯降低作用,從而能改善患兒的預後。
목적:탐토오사타정대농독성휴극영유인백개소-1(IL-1)、종류배사인자α(TNF-α)급강개소원(PCT)적영향。방법장60례농독성휴극환인안수궤수자표법분위대조조화치료조,매조30례。대조조급여항휴극화병인치료,치료조재대조조치료적기출상,급여오사타정2만 U·kg-1가입5%포도당주사액50 mL중정맥적주,q8h。2조균5 d 위1개료정。2조환인분별우입주ICU시급치료5 d 후채집정맥혈4 mL,측정TNF-α、IL-1급PCT,관찰치료전후TNF-α、IL-1급PCT수평적변화。결과2조치료전IL-1、TNF-α화PCT수평적변화비교차이균무통계학의의(균 P>0.05);치료조치료5 d 후 IL-1、TNF-α화 PCT 분별위(86.48±17.29)pg·L-1、(105.86±20.79)pg·L-1화(5.33±0.85)ng·mL-1,대조조치료5 d 후IL-1、TNF-α화PCT분별위(112.34±18.54)pg·L-1、(189.04±28.36)pg·L-1화(8.54±1.43)ng·mL-1,치료조명현저우대조조(균P<0.05)。결론오사타정대농독성휴극영유인IL-1、TNF-α급PCT유명현강저작용,종이능개선환인적예후。
Objective To investigate the effects of ulinastatin on the levels of interleukin-1(IL-1), tumor necrosis factor-α(TNF-α) and procalcitonin(PCT) in infants with septic shock. Methods Sixty infants with septic shock were randomly divided into two groups,with 30 infants in each group. The control group was given anti-shock and etiological treatment. On this basis,the treatment group was given intravenous drip of ulinastatin (20 000 U·kg-1 in 50 mL of 5% glucose solution, once every 8 hours).The course of treatment was 5 days.Venous blood samples(4 mL)were taken after ICU admission and treatment for 5 days to determine the levels of IL-1,TNF-α and PCT in both groups. Results There were no significant differences in the levels of IL-1,TNF-α and PCT between the two groups before treatment(P>0.05). Compared with control group,the levels of IL-1,TNF-αand PCT significantly decreased in treatment group after treatment for 5 days [(86.48±17.29)pg·L-1 vs(112.34±18.54)pg·L-1, (105.86±20.79)pg·L-1 vs (189.04±28.36)pg·L-1 and (5.33±0.85)ng·mL-1 vs (8.54±1.43)ng·mL-1, respectively; P<0.05]. Conclusions Ulinastatin treatment can reduce the levels of IL-1, TNF-α and PCT and improve the prognosis in infants with septic shock.