中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2014年
6期
598-601
,共4页
结直肠肿瘤%肝转移,同时性%肝细胞生长因子%c-Met
結直腸腫瘤%肝轉移,同時性%肝細胞生長因子%c-Met
결직장종류%간전이,동시성%간세포생장인자%c-Met
Colorectal neoplasms%Synchronous liver metastasis%Hepatocyte growth factor%c-Met
目的：探讨肝细胞生长因子及其受体c-Met（HGF-cMet）的表达与结直肠癌同时性肝转移的关系。方法2001年6月至2010年6月间有30例结直肠癌同性性肝转移患者在山东省肿瘤医院接受原发癌和肝转移癌一期根治性切除术，根据其是否伴有区域淋巴结转移分为实验Ⅰ组（T1～T4N1～N2M1，21例）和实验Ⅱ组（T1～T4N0M1，9例）。并选取与实验Ⅰ组匹配的T1～T4N1～N2M0患者（21例）和T1～T4N0M0患者（21例）以及与实验Ⅱ组匹配的T1～T4N0M0患者（9例）作为对照。应用免疫组织化学方法检测原发灶、淋巴结转移灶及其肝转移灶中HGF和c-Met的蛋白表达水平。结果实验Ⅰ组（T1～T4N1～N2M1）原发灶HGF阳性表达率[71％（15/21）]明显高于其匹配的T1～T4N1～N2M0对照组[43％（9/21）]和T1～T4N0M0对照组[19％（4/21）]（均P＜0．05）；且c-Met阳性表达率[90％（19/21）]也明显高于 T1～T4N0M0对照组[43％（9/21），P＜0．05]，但与T1～T4N1～N2M0对照组[86％（18/21）]的差异则无统计学意义（P＞0．05）。实验Ⅱ组（T1～T4N0M1）与其对照组（T1～T4N0M0）原发灶HGF阳性表达率（6/9比5/9，P＞0．05）和c-Met阳性表达率（8/9比6/9，P＞0．05）的差异均无统计学意义。实验Ⅰ组患者原发灶、淋巴结转移灶及肝转移灶中HGF和c-Met表达一致率分别为81％（17/21）和76％（16/21）。结论 HGF及其受体c-Met可能对存在区域淋巴结转移的结直肠癌同时性肝转移的发生具有一定作用，而对无淋巴结转移的结直肠癌发生肝转移的作用可能较小。
目的：探討肝細胞生長因子及其受體c-Met（HGF-cMet）的錶達與結直腸癌同時性肝轉移的關繫。方法2001年6月至2010年6月間有30例結直腸癌同性性肝轉移患者在山東省腫瘤醫院接受原髮癌和肝轉移癌一期根治性切除術，根據其是否伴有區域淋巴結轉移分為實驗Ⅰ組（T1～T4N1～N2M1，21例）和實驗Ⅱ組（T1～T4N0M1，9例）。併選取與實驗Ⅰ組匹配的T1～T4N1～N2M0患者（21例）和T1～T4N0M0患者（21例）以及與實驗Ⅱ組匹配的T1～T4N0M0患者（9例）作為對照。應用免疫組織化學方法檢測原髮竈、淋巴結轉移竈及其肝轉移竈中HGF和c-Met的蛋白錶達水平。結果實驗Ⅰ組（T1～T4N1～N2M1）原髮竈HGF暘性錶達率[71％（15/21）]明顯高于其匹配的T1～T4N1～N2M0對照組[43％（9/21）]和T1～T4N0M0對照組[19％（4/21）]（均P＜0．05）；且c-Met暘性錶達率[90％（19/21）]也明顯高于 T1～T4N0M0對照組[43％（9/21），P＜0．05]，但與T1～T4N1～N2M0對照組[86％（18/21）]的差異則無統計學意義（P＞0．05）。實驗Ⅱ組（T1～T4N0M1）與其對照組（T1～T4N0M0）原髮竈HGF暘性錶達率（6/9比5/9，P＞0．05）和c-Met暘性錶達率（8/9比6/9，P＞0．05）的差異均無統計學意義。實驗Ⅰ組患者原髮竈、淋巴結轉移竈及肝轉移竈中HGF和c-Met錶達一緻率分彆為81％（17/21）和76％（16/21）。結論 HGF及其受體c-Met可能對存在區域淋巴結轉移的結直腸癌同時性肝轉移的髮生具有一定作用，而對無淋巴結轉移的結直腸癌髮生肝轉移的作用可能較小。
목적：탐토간세포생장인자급기수체c-Met（HGF-cMet）적표체여결직장암동시성간전이적관계。방법2001년6월지2010년6월간유30례결직장암동성성간전이환자재산동성종류의원접수원발암화간전이암일기근치성절제술，근거기시부반유구역림파결전이분위실험Ⅰ조（T1～T4N1～N2M1，21례）화실험Ⅱ조（T1～T4N0M1，9례）。병선취여실험Ⅰ조필배적T1～T4N1～N2M0환자（21례）화T1～T4N0M0환자（21례）이급여실험Ⅱ조필배적T1～T4N0M0환자（9례）작위대조。응용면역조직화학방법검측원발조、림파결전이조급기간전이조중HGF화c-Met적단백표체수평。결과실험Ⅰ조（T1～T4N1～N2M1）원발조HGF양성표체솔[71％（15/21）]명현고우기필배적T1～T4N1～N2M0대조조[43％（9/21）]화T1～T4N0M0대조조[19％（4/21）]（균P＜0．05）；차c-Met양성표체솔[90％（19/21）]야명현고우 T1～T4N0M0대조조[43％（9/21），P＜0．05]，단여T1～T4N1～N2M0대조조[86％（18/21）]적차이칙무통계학의의（P＞0．05）。실험Ⅱ조（T1～T4N0M1）여기대조조（T1～T4N0M0）원발조HGF양성표체솔（6/9비5/9，P＞0．05）화c-Met양성표체솔（8/9비6/9，P＞0．05）적차이균무통계학의의。실험Ⅰ조환자원발조、림파결전이조급간전이조중HGF화c-Met표체일치솔분별위81％（17/21）화76％（16/21）。결론 HGF급기수체c-Met가능대존재구역림파결전이적결직장암동시성간전이적발생구유일정작용，이대무림파결전이적결직장암발생간전이적작용가능교소。
Objective To investigate the association between expression of hepatocyte growth factor (HGF) and its receptor c-Met and primary colorectal cancers with synchronous liver metastases. Methods A total of 30 colorectal cancer patients with synchronous liver metastasis underwent radical resection of primary cancer and liver cancer in our hospital from June 2001 to June 2010. According to lymphatic metastasis, patients were divided into group A(T1~T4N1~N2M1, n=21) and group B(T1~T4N0M1, n=9). Twenty-one matched T1~T4N1~N2M0 and 21 T1~T4N0M0 patients were used as the controls of group A. Nine matched T1~T4N0M0 patients were used as the controls of group B. Expressions of HGF and c-Met in tissues of primary loci, liver loci and metastatic loci were detected by immunohistochemistry. Results In primary loci of group A, the positive rate of HGF was significantly higher than that of T1~T4N1~N2M0 and T1~T4N0M0 controls [71%(15/21) vs. 43%(9/21), 19%(4/21), all P<0.05]. The positive rate of c-MET [90%(19/21)] was significantly higher compared to T1~T4N0M0 control [43%(9/21), P<0.05], while not significantly different compared to T1~T4N1~N2M0 control [86%(18/21)]. In primary loci of group B, positive rates of HGF and c-MET were not significantly different as co mpared to T1~T4N0M0 control[6/9 vs. 5/9, P>0.05;8/9 vs. 6/9, P>0.05]. Concordance of HGF and c-MET expression in group A among primary loci, lymphatic metastatic loci and hepatic metastatic loci was 81%(17/21) and 76%(16/21). Conclusion HGF-c-Met may play a role in colorectal cancer patients with synchronous liver metastasis who have regional lymphatic metastasis, and may have few effect on colorectal cancer with synchronous liver metastasis without corresponding lymphatic metastasis.
