光谱学与光谱分析
光譜學與光譜分析
광보학여광보분석
SPECTROSCOPY AND SPECTRAL ANALYSIS
2014年
7期
1973-1977
,共5页
林凌%武若楠%李永城%周梅%李刚
林凌%武若楠%李永城%週梅%李剛
림릉%무약남%리영성%주매%리강
动态光谱(DS )%血液成分无创检测%补偿拟合提取%光电容积脉搏波(PPG )%最小二乘法
動態光譜(DS )%血液成分無創檢測%補償擬閤提取%光電容積脈搏波(PPG )%最小二乘法
동태광보(DS )%혈액성분무창검측%보상의합제취%광전용적맥박파(PPG )%최소이승법
Dynamic spectrum (DS )%Noninvasive blood compositions measurement%Photoelectric plethysmography (PPG )%Compensation-fitting extraction%Least squares method
高信噪比的动态光谱（dynamic spectrum ，DS ）提取是实现高精度动态光谱血液成分无创检测的一个关键。为了进一步提高提取的精度和速度，从原理上分析了各单波长光电容积脉搏波（photoelectric ple-thysmography ，PPG）的线性相似性，并基于此性质提出了补偿拟合法：首先按照PPG单周期采样点数进行滑动平均得到漂移基线进行补偿，除去基线漂移；其次用各波长对数PPG与全波长叠加平均模板PPG进行最小二乘拟合，提取一次项系数构成DS。利用拟合提取法对近红外和可见光波段各25组PPG数据样本进行DS提取实验验证，并将结果与单沿提取法进行平滑性指标的对比，结果表明：近红外和可见光波段补偿拟合法获取DS的平均方差分别为单沿提取法的77.9％和59.5％，稳定提高了DS的平滑性；近红外和可见光波段补偿拟合法处理时间分别可以达到单沿提取法的10％和20％，处理速度得到显著改善。补偿拟合法在单沿提取法的基础上稳定提高了DS的信噪比，改善了DS提取质量，缩减了提取时间，并简化了处理步骤，有望推动DS无创血液成分检测的发展。
高信譟比的動態光譜（dynamic spectrum ，DS ）提取是實現高精度動態光譜血液成分無創檢測的一箇關鍵。為瞭進一步提高提取的精度和速度，從原理上分析瞭各單波長光電容積脈搏波（photoelectric ple-thysmography ，PPG）的線性相似性，併基于此性質提齣瞭補償擬閤法：首先按照PPG單週期採樣點數進行滑動平均得到漂移基線進行補償，除去基線漂移；其次用各波長對數PPG與全波長疊加平均模闆PPG進行最小二乘擬閤，提取一次項繫數構成DS。利用擬閤提取法對近紅外和可見光波段各25組PPG數據樣本進行DS提取實驗驗證，併將結果與單沿提取法進行平滑性指標的對比，結果錶明：近紅外和可見光波段補償擬閤法穫取DS的平均方差分彆為單沿提取法的77.9％和59.5％，穩定提高瞭DS的平滑性；近紅外和可見光波段補償擬閤法處理時間分彆可以達到單沿提取法的10％和20％，處理速度得到顯著改善。補償擬閤法在單沿提取法的基礎上穩定提高瞭DS的信譟比，改善瞭DS提取質量，縮減瞭提取時間，併簡化瞭處理步驟，有望推動DS無創血液成分檢測的髮展。
고신조비적동태광보（dynamic spectrum ，DS ）제취시실현고정도동태광보혈액성분무창검측적일개관건。위료진일보제고제취적정도화속도，종원리상분석료각단파장광전용적맥박파（photoelectric ple-thysmography ，PPG）적선성상사성，병기우차성질제출료보상의합법：수선안조PPG단주기채양점수진행활동평균득도표이기선진행보상，제거기선표이；기차용각파장대수PPG여전파장첩가평균모판PPG진행최소이승의합，제취일차항계수구성DS。이용의합제취법대근홍외화가견광파단각25조PPG수거양본진행DS제취실험험증，병장결과여단연제취법진행평활성지표적대비，결과표명：근홍외화가견광파단보상의합법획취DS적평균방차분별위단연제취법적77.9％화59.5％，은정제고료DS적평활성；근홍외화가견광파단보상의합법처리시간분별가이체도단연제취법적10％화20％，처리속도득도현저개선。보상의합법재단연제취법적기출상은정제고료DS적신조비，개선료DS제취질량，축감료제취시간，병간화료처리보취，유망추동DS무창혈액성분검측적발전。
Extraction method for dynamic spectrum (DS) with a high signal to noise ratio is a key to achieving high-precision noninvasive detection of blood components .In order to further improve the accuracy and speed of DS extraction ,linear similarity between photoelectric plethysmographys (PPG) at each two different wavelengths was analyzed in principle ,and an experimental verification was conducted .Based on this property ,the method of compensation-fitting extraction was proposed .Firstly ,the baseline of PPG at each wavelength is estimated and compensated using single-period sampling average ,which would remove the effect of baseline drift caused by motion artifact .Secondly ,the slope of least squares fitting between each single-wavelength PPG and full-wavelength averaged PPG is acquired to construct DS ,which would significantly suppress random noise .Contrast ex-periments were conducted on 25 samples in NIR wave band and Vis wave band respectively .Flatness and processing time of DS using compensation-fitting extraction were compared with that using single-trial estimation .In NIR band ,the average variance using compensation-fitting estimation was 69 .0% of that using single-trial estimation ,and in Vis band it was 57 .4% ,which shows that the flatness of DS is steadily improved .In NIR band ,the data processing time using compensation-fitting extraction could be reduced to 10% of that using single-trial estimation ,and in Vis band it was 20% ,which shows that the time for data processing is significantly reduced .Experimental results show that ,compared with single-trial estimation method ,dynamic spectrum compensation-fitting extraction could steadily improve the signal to noise ratio of DS ,significantly improve estimation quality ,reduce data processing time ,and simplify procedure .Therefore ,this new method is expected to promote the develop-ment of noninvasive blood components measurement .
