医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2014年
16期
173-174
,共2页
高原肺动脉高压%缺氧诱导因子-1α%血管内皮生长因子
高原肺動脈高壓%缺氧誘導因子-1α%血管內皮生長因子
고원폐동맥고압%결양유도인자-1α%혈관내피생장인자
high altitude pulmonary hypertension%hypoxia inducible factor -1α%vascular endothelial growth factor
目的：探讨血清缺氧诱导因子-1α(HIF-1α)及血管内皮生长因子（VEGF）在高原肺动脉高压发病机制中的作用。方法：经彩色多普勒超声心动仪检查将居住于海拔2500～4250m的高原地区常驻人群分为四组：健康对照组（无肺动脉高压,a组）、轻度肺动脉高压组（b组）、中度肺动脉高压组（c组）、重度肺动脉高压组（d组）。采用双抗体夹心酶联免疫吸附法(ELSIA)检测68例肺动脉高压患者及20例健康对照组血清HIF-1α、VEGF浓度，并进行相关分析。结果：b组、c组及d组血清HIF-1α及VEGF浓度均高于对照组(P<0．01)，肺动脉高压患者随肺动脉压力的升高HIF-1α及VEGF浓度增高，肺动脉压力高低与血清HIF-1α及VEGF浓度均呈显著正相关(r=0．628及0.536，均P<0．01)。结论：血清HIF-1α、VEGF与高原肺动脉高压的形成及发展密切相关。
目的：探討血清缺氧誘導因子-1α(HIF-1α)及血管內皮生長因子（VEGF）在高原肺動脈高壓髮病機製中的作用。方法：經綵色多普勒超聲心動儀檢查將居住于海拔2500～4250m的高原地區常駐人群分為四組：健康對照組（無肺動脈高壓,a組）、輕度肺動脈高壓組（b組）、中度肺動脈高壓組（c組）、重度肺動脈高壓組（d組）。採用雙抗體夾心酶聯免疫吸附法(ELSIA)檢測68例肺動脈高壓患者及20例健康對照組血清HIF-1α、VEGF濃度，併進行相關分析。結果：b組、c組及d組血清HIF-1α及VEGF濃度均高于對照組(P<0．01)，肺動脈高壓患者隨肺動脈壓力的升高HIF-1α及VEGF濃度增高，肺動脈壓力高低與血清HIF-1α及VEGF濃度均呈顯著正相關(r=0．628及0.536，均P<0．01)。結論：血清HIF-1α、VEGF與高原肺動脈高壓的形成及髮展密切相關。
목적：탐토혈청결양유도인자-1α(HIF-1α)급혈관내피생장인자（VEGF）재고원폐동맥고압발병궤제중적작용。방법：경채색다보륵초성심동의검사장거주우해발2500～4250m적고원지구상주인군분위사조：건강대조조（무폐동맥고압,a조）、경도폐동맥고압조（b조）、중도폐동맥고압조（c조）、중도폐동맥고압조（d조）。채용쌍항체협심매련면역흡부법(ELSIA)검측68례폐동맥고압환자급20례건강대조조혈청HIF-1α、VEGF농도，병진행상관분석。결과：b조、c조급d조혈청HIF-1α급VEGF농도균고우대조조(P<0．01)，폐동맥고압환자수폐동맥압력적승고HIF-1α급VEGF농도증고，폐동맥압력고저여혈청HIF-1α급VEGF농도균정현저정상관(r=0．628급0.536，균P<0．01)。결론：혈청HIF-1α、VEGF여고원폐동맥고압적형성급발전밀절상관。
Objective To investigate the the role of serum hypoxia inducible factor -1α (HIF-1α) and vascular endothelial growth factor (VEGF) in the pathogenesis of high altitude pulmonary hypertension. Methods: divided the resident population of plateau area lived at an altitude of 2500~4250m into four groups by Color Doppler echocardiography examination: normal control group (without pulmonary hypertension, group A), mild pulmonary hypertension group (group B), moderate pulmonary hypertension group (group C ), severe pulmonary artery hypertension group ( group D) . Using double antibody sandwich enzyme linked immunosorbent assay (ELSIA) to detect the concentration of serum HIF-1 α and VEGF in 68 patients with pulmonary hypertension and 20 healthy control group, and then correlation analysis. Results: the concentrations of serum HIF-1α and VEGF in group b, c group and d group were higher those in the control group (P<0.01), HIF-1α and VEGF concentration increased With the increase of pulmonary artery pressure in Patients with pulmonary hypertension (r=0.628 and 0.536, P<0.01). Conclusion: HIF-1α and VEGF in Serum is closely related to the occurrence and development of high altitude pulmonary hypertension.
