CAJ | 학술논문

目的：探讨蓝田瑶族盐敏感性的血压差异及其对肾脏的损害。方法收集1030名符合条件的瑶族居民，以相应的1280名汉族居民为对照，统一进行低盐饮食(摄盐量3g/dx7d)继而高盐饮食(摄盐18g/dx7d)干预，定时监测血压，收集两个阶段的尿液及血液标本，检测血β2-微球蛋白(β2-MG)﹑尿β2-MG﹑尿微白蛋白(Alb)﹑尿肌酐(Cr)及尿Alb/Cr等指标。结果瑶族盐敏感(SS)者检出率为16.5%，明显低于汉族(P <0.05)。SS者从低盐到高盐饮食变化后，收缩压或舒张压均明显上升，盐敏感指标△H-LMABP和△H-BMABP分别为6.9±4.3mmHg及6.3±4.4mmHg，均高于盐不敏感(SR)组的0.4±4.2mmHg及1.0±3.7mmHg(P<0.01)。高盐饮食后，SS者的尿β2-MG和尿Alb/Cr也明显高于SR者(P<0.05)，但其上升幅度小于汉族SS者(P<0.05)。结论蓝田瑶族的盐敏感性及高盐对肾脏损害程度具有自身的特点，可能与其特殊的饮食习惯及高血压相关基因多态性有关。
목적：탐토람전요족염민감성적혈압차이급기대신장적손해。방법수집1030명부합조건적요족거민，이상응적1280명한족거민위대조，통일진행저염음식(섭염량3g/dx7d)계이고염음식(섭염18g/dx7d)간예，정시감측혈압，수집량개계단적뇨액급혈액표본，검측혈β2-미구단백(β2-MG)﹑뇨β2-MG﹑뇨미백단백(Alb)﹑뇨기항(Cr)급뇨Alb/Cr등지표。결과요족염민감(SS)자검출솔위16.5%，명현저우한족(P <0.05)。SS자종저염도고염음식변화후，수축압혹서장압균명현상승，염민감지표△H-LMABP화△H-BMABP분별위6.9±4.3mmHg급6.3±4.4mmHg，균고우염불민감(SR)조적0.4±4.2mmHg급1.0±3.7mmHg(P<0.01)。고염음식후，SS자적뇨β2-MG화뇨Alb/Cr야명현고우SR자(P<0.05)，단기상승폭도소우한족SS자(P<0.05)。결론람전요족적염민감성급고염대신장손해정도구유자신적특점，가능여기특수적음식습관급고혈압상관기인다태성유관。
Objective To study the difference of salt-sensitivity (SS) and its effect on alteration of blood pressure and renal injury in Lantian Yao population. Methods This study was performed in 1030 Yao residents who were determined by unified standard and compared with 1280 Han residents. Al the participants carried out two stages of dietary intervention including low salt diet (salt 3g/d x 7d) and fol owing high salt diet (salt 18g/d x 7d). Daily blood pressure was measured, while blood and urine β2-MG, urine Alb, Cr and Alb/Cr were examined. Results The percentage of SS Yao participants was 16.5%, which was lower than Han ones (P <0.05). From the diet of low salt to high salt, both of systolic blood pressure and diastolic blood pressure remarkably increased. Meanwhile, in the SS group, two SS indexex of △H-LMABP and △H-BMABP were 6.9±4.3 mmHg and 6.3±4.4 mmHg, which were higher than those in salt-resistance (SR) group representing as 0.4±4.2 mmHg and 1.0±3.7 mmHg, respectively (P <0.01). In addition, a rise in urine β2-MG and Alb/Cr was observed in SS Yao group compared with SR group (P <0.05), however, the variabilities of rising level were not as large as those in SS Han subjects (P <0.05). Conclusion The differences of salt-sentivity and high salt effect on renal injury in Lantian Yao population are distinctive, which may result from the unique dietary and polymorphism of hypertention-relative genes.