CAJ | 학술논문

癫痫性脑病(EES)是一组与严重的癫痫源性的脑部疾患，伴随进行性加剧的认知和行为障碍。EES发生认知障碍的机制目前尚不甚明了。本文对癫痫性脑病脑功能的神经影像学研究进行综述。尽管癫痫活动可能单独起源于不同脑区，但癫痫活动似乎以综合征的特定的方式进行传播。在部分癫痫性脑病中发现，癫痫的异常放电与脑默认网络的中断密切相关。对于其他类型的癫痫，尚有其他机制认为癫痫异常活动与认知障碍相关，如异常的连接模式及丘脑皮层网络连接的活动受抑。对于功能影像学对于癫痫异常活动的传播机制及对认知功能影像尚需要进一步深入研究。
전간성뇌병(EES)시일조여엄중적전간원성적뇌부질환，반수진행성가극적인지화행위장애。EES발생인지장애적궤제목전상불심명료。본문대전간성뇌병뇌공능적신경영상학연구진행종술。진관전간활동가능단독기원우불동뇌구，단전간활동사호이종합정적특정적방식진행전파。재부분전간성뇌병중발현，전간적이상방전여뇌묵인망락적중단밀절상관。대우기타류형적전간，상유기타궤제인위전간이상활동여인지장애상관，여이상적련접모식급구뇌피층망락련접적활동수억。대우공능영상학대우전간이상활동적전파궤제급대인지공능영상상수요진일보심입연구。
Epileptic encephalopathies (EEs) represent a group of severe epileptic disorders associated with cognitive and behavioral disturbances. The mechanisms of cognitive disability in EEs remain unclear. This review summarized neuroimaging studies that have tried to describe specific fingerprints of brain activation in EE. Although the epileptic activity can be generated individual y in different brain regions, it seems likely that the activity propagates in a syndrome-specific way. In some EEs, the epileptiform discharges were associated with an interruption of activity in the default mode network. In another EE, other mechanisms seem to underlie cognitive disability associated with epileptic activity, for example, abnormal connectivity pattern or interfering activity in the thalamocortical network. Further neuroimaging studies are needed to investigate the short-term and long-term impact of epileptic activity on cognition and development.