医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2014年
17期
53-54
,共2页
支气管哮喘%一氧化氮%白细胞介素-8%糖皮质激素%粒-巨噬细胞集落刺激因子
支氣管哮喘%一氧化氮%白細胞介素-8%糖皮質激素%粒-巨噬細胞集落刺激因子
지기관효천%일양화담%백세포개소-8%당피질격소%립-거서세포집락자격인자
bronchial asthma%nitric oxide(NO) interleukin-8(IL-8)%Glucocorticoids Granulocyte-macrophage%colony stimulating%factor(GM-CSF)
目的：观察支气管哮喘患儿血清IL-6﹑IL-8和GM-CSF水平的变化。方法：采用化学法和放射免疫法分析，先对31例支气管哮喘患儿进行了吸入糖皮质激素前后血清NO﹑IL-8和GM-CSF水平检测，并与35名正常健康儿作比较。结果：支气管哮喘患儿在吸入糖皮质激素前血清NO﹑IL-8和GM-CSF水平均非常显著的高于正常儿组( P<0.01)，经吸入糖皮质激素2个月后与正常人比较仍有显著差异( P<0.05)且血清N O水平与I L-8﹑G M-C S F水平呈显著正相关(r=0.5134,0.6012,P<0.01)。结论：吸入糖皮质激素是治疗支气管哮喘的重要手段，其治疗作用与下调NO﹑IL-8和GM-CSF水平有关。
目的：觀察支氣管哮喘患兒血清IL-6﹑IL-8和GM-CSF水平的變化。方法：採用化學法和放射免疫法分析，先對31例支氣管哮喘患兒進行瞭吸入糖皮質激素前後血清NO﹑IL-8和GM-CSF水平檢測，併與35名正常健康兒作比較。結果：支氣管哮喘患兒在吸入糖皮質激素前血清NO﹑IL-8和GM-CSF水平均非常顯著的高于正常兒組( P<0.01)，經吸入糖皮質激素2箇月後與正常人比較仍有顯著差異( P<0.05)且血清N O水平與I L-8﹑G M-C S F水平呈顯著正相關(r=0.5134,0.6012,P<0.01)。結論：吸入糖皮質激素是治療支氣管哮喘的重要手段，其治療作用與下調NO﹑IL-8和GM-CSF水平有關。
목적：관찰지기관효천환인혈청IL-6﹑IL-8화GM-CSF수평적변화。방법：채용화학법화방사면역법분석，선대31례지기관효천환인진행료흡입당피질격소전후혈청NO﹑IL-8화GM-CSF수평검측，병여35명정상건강인작비교。결과：지기관효천환인재흡입당피질격소전혈청NO﹑IL-8화GM-CSF수평균비상현저적고우정상인조( P<0.01)，경흡입당피질격소2개월후여정상인비교잉유현저차이( P<0.05)차혈청N O수평여I L-8﹑G M-C S F수평정현저정상관(r=0.5134,0.6012,P<0.01)。결론：흡입당피질격소시치료지기관효천적중요수단，기치료작용여하조NO﹑IL-8화GM-CSF수평유관。
objective: To observe the effect of inhalation of glucocorticoids on the levels of serum NO﹑IL-8 and GM-CSF in Bronchial Asthmatic children. Methods : Serum NO(with chemistry) serum IL-8﹑GM-CSF(with RIA) levels were determined in 31 patients and compared 35 controls. Results: before inhalation of glucocorticoids , the serum NO﹑IL-8 and GM-CSF levels were significantly higher than those in controls(P<0.01).after 2mouths of inhalation of glucocorticoids the serum NO﹑IL-8 and GM-CSF levels though dropped markedly but remained apparently higher than those in controls(P<0.05).Serum NO levels were positively correlated with serum NO﹑IL-8 and GM-CSF levels(r=0.5134,0.6012,P<0.01).Conclusions:Inhalation of glucocorticoids is an important means for bronchial asthma and the therapeutic effects closely related to the down regulation of levels NO﹑IL-8 and GM-CSF.
