CAJ | 학술논문

目的：探讨缺血性脑卒中患者总胆固醇/高密度脂蛋白醇（TC/HDL-C）、甘油三酯/高密度脂蛋白醇（TG/HDL-C ）比值与与血浆中高密度脂蛋白（HDL ）亚类含量的关系。方法根据TC/HDL-C和TG/HDL-C比值分别将61例缺血性脑卒中患者分为高、中、低比值组，采用双向电泳-免疫印迹检测法分析HDL亚类的组成、含量及分布特征。结果在缺血性脑卒中患者中，随着TC/HDL-C或TG/HDL-C比值增大，小颗粒的preβ1-HDL含量呈升高趋势，大颗粒的HDL2 a 、HDL2 b含量呈降低趋势。相关性分析发现，缺血性脑卒中患者血浆TG、TC/HDL-C和TG/HDL-C与小颗粒preβ1-HDL含量呈正相关（ P ＜0．05），而与大颗粒HDL2a及HDL2b含量呈负相关（ P ＜0．05）；HDL-C和apoA1与HDL各亚类呈正相关（ P＜0．05）。结论缺血性脑卒中患者中TC/HDL-C或TG/HDL-C比值的升高与HDL成熟代谢受阻、胆固醇逆转运作用减弱有关。
목적：탐토결혈성뇌졸중환자총담고순/고밀도지단백순（TC/HDL-C）、감유삼지/고밀도지단백순（TG/HDL-C ）비치여여혈장중고밀도지단백（HDL ）아류함량적관계。방법근거TC/HDL-C화TG/HDL-C비치분별장61례결혈성뇌졸중환자분위고、중、저비치조，채용쌍향전영-면역인적검측법분석HDL아류적조성、함량급분포특정。결과재결혈성뇌졸중환자중，수착TC/HDL-C혹TG/HDL-C비치증대，소과립적preβ1-HDL함량정승고추세，대과립적HDL2 a 、HDL2 b함량정강저추세。상관성분석발현，결혈성뇌졸중환자혈장TG、TC/HDL-C화TG/HDL-C여소과립preβ1-HDL함량정정상관（ P ＜0．05），이여대과립HDL2a급HDL2b함량정부상관（ P ＜0．05）；HDL-C화apoA1여HDL각아류정정상관（ P＜0．05）。결론결혈성뇌졸중환자중TC/HDL-C혹TG/HDL-C비치적승고여HDL성숙대사수조、담고순역전운작용감약유관。
Objective To investigate the relationship between HDL subclasses and TC/HDL-C ,TG/HDL-C ratio in ischemic stroke patients .Methods According to the ratio of TC/HDL-C and TG/HDL-C ,61 ischemic stroke patients were divided into three groups ,respectively .HDL subclasses were quantitated by two-dimension-al gel electrophoresis .Results Accompanied with the increase of TC/HDL-C and TG/HDL-C ratio in ischemic stroke patients ,the levels of small-sized preβ1 -HDL showed a trend of rise ,and the contents of large-sized of HDL2a and HDL2b showed a trend of decrease .Analysis of correlation found that TG ,TC/HDL-C and TG/HDL-C showed a positive correlation with small-sized preβ1 -HDL ( P <0 .05 ) ,but a negative correlation with large-sized HDL2a and HDL2b ( P <0 .05) ,HDL-C showed a positive correlation with all particles of HDL in isch-emic stroke patients ( P <0 .05 ) . Conclusion The increase of TC/HDL -C and TG/HDL -C were associated with the mature of HDL metabolism and the weakened of reverse cholesterol transport .