CAJ | 학술논문

MicroRNAs（ miRNAs）是一种长约22个核苷酸，内源性的非编码RNA基因，主要通过与靶基因mRNA 3′非翻译区（ UTR）互补序列结合，在转录后水平调节基因表达。 miRNAs广泛参与胚胎发育、细胞增殖、分化凋亡、细胞周期、新生血管生成等多种生物学过程。近年来，大量研究表明miRNAs与肿瘤关系密切。 miRNA-195是miR-15a、15b、16、195、497家族中的重要一员，其在肿瘤的发生发展以及恶性生物学行为调控中发挥着重要的作用，因此，阐明miRNA-195在肿瘤演进过程中的作用将有助于更加深入全面地认识肿瘤发生、发展的分子机制，为肿瘤的治疗提供理论依据。
MicroRNAs（ miRNAs）시일충장약22개핵감산，내원성적비편마RNA기인，주요통과여파기인mRNA 3′비번역구（ UTR）호보서렬결합，재전록후수평조절기인표체。 miRNAs엄범삼여배태발육、세포증식、분화조망、세포주기、신생혈관생성등다충생물학과정。근년래，대량연구표명miRNAs여종류관계밀절。 miRNA-195시miR-15a、15b、16、195、497가족중적중요일원，기재종류적발생발전이급악성생물학행위조공중발휘착중요적작용，인차，천명miRNA-195재종류연진과정중적작용장유조우경가심입전면지인식종류발생、발전적분자궤제，위종류적치료제공이론의거。
MicroRNAs(miRNAs),which are approximately 22 nucleotides in length,are a class of endogenous, small, noncoding RNAs.MiRNAs can negatively regulate gene expression at the post-transcriptional and/or translational level by binding loosely complementary sequences in the 3′untranslated regions(UTR)of target mRNAs.It has been demonstrated that miRNAs regulate a wide range of biological processes,including embryonic development,angiogenesis,cell differentiation,proliferation and apoptosis. Growing evidences have indicated a strong association between miRNAs and cancers .MicroRNA-195 ( miR-195)is an important member of the miR-15a,15b,16,195,497 family,which plays an important role in the occur and development progress of tumors and regulation of malignant biological behaviours .Therefore , in-depth understanding of the mechanisms and roles of miR-195 on tumor development will provide a theoretical basis for clinical intervention of miRNA in tumor treatment .