中华耳科学杂志
中華耳科學雜誌
중화이과학잡지
CHINESE JOURNAL OF OTOLOGY
2014年
2期
239-241
,共3页
王鸿南%吴玮%韩浩伦%李保卫%王刚%孙喆喆%孟令照%王磊%陈艳芳%丁瑞英%孙建芝
王鴻南%吳瑋%韓浩倫%李保衛%王剛%孫喆喆%孟令照%王磊%陳豔芳%丁瑞英%孫建芝
왕홍남%오위%한호륜%리보위%왕강%손철철%맹령조%왕뢰%진염방%정서영%손건지
失匹配负波%听力学%注意力%正常人
失匹配負波%聽力學%註意力%正常人
실필배부파%은역학%주의력%정상인
Mismatch Negativity (MMN)%Audiology%Normal People%Attention
目的：探讨失匹配负波（mismatch negativity，MMN）检查在正常青年人中的特点，并分析阅读状态和集中注意力时MMN检查的结果有无差异。方法对12例青年女性(年龄29-31y，平均30.08y)和18例青年男性(年龄27-34y，平均30.22y)行MMN检查，所有受试者均行听性脑干反应（ABR）阈值检查，确定ABR阈值，MMN检查在受试者在阅读状态和集中注意力状态时分别检测，采用oddball刺激方式，给予短纯音刺激，偏差刺激声为2000Hz，概率为20%，标准刺激为1000 Hz，概率为80%，刺激频率为1.1次/s，刺激声强度为ABR阈上50dB nHL；观察MMN潜伏期及波幅的特点。结果所有受试者ABR阈值均≤25 dB nHL。每例受试者均可引出MMN波形，女性在阅读状态下MMN潜伏期为159.57±20.64 ms，波幅为3.82±1.38 uV，在集中注意力状态下MMN潜伏期为155.96±17.51 ms，波幅为4.28±1.89 uV，经配对t检验潜伏期和波幅在两种状态下无显著差异；男性在阅读状态下MMN潜伏期为150.48±19.57 ms，波幅为3.75±1.27 uV，在集中注意力状态下MMN潜伏期为144.81±15.42 ms，波幅为3.99±1.34 uV，经配对t检验潜伏期和波幅在两种状态下无显著差异；经独立样本t检验，男女在上述两种状态下MMN波幅和潜伏期均无显著差异。结论正常青年男女均能引出MMN波形，男女之间MMN检查的波幅和潜伏期无差异，阅读状态和集中注意力状态对MMN检查的波幅和潜伏期无影响。
目的：探討失匹配負波（mismatch negativity，MMN）檢查在正常青年人中的特點，併分析閱讀狀態和集中註意力時MMN檢查的結果有無差異。方法對12例青年女性(年齡29-31y，平均30.08y)和18例青年男性(年齡27-34y，平均30.22y)行MMN檢查，所有受試者均行聽性腦榦反應（ABR）閾值檢查，確定ABR閾值，MMN檢查在受試者在閱讀狀態和集中註意力狀態時分彆檢測，採用oddball刺激方式，給予短純音刺激，偏差刺激聲為2000Hz，概率為20%，標準刺激為1000 Hz，概率為80%，刺激頻率為1.1次/s，刺激聲彊度為ABR閾上50dB nHL；觀察MMN潛伏期及波幅的特點。結果所有受試者ABR閾值均≤25 dB nHL。每例受試者均可引齣MMN波形，女性在閱讀狀態下MMN潛伏期為159.57±20.64 ms，波幅為3.82±1.38 uV，在集中註意力狀態下MMN潛伏期為155.96±17.51 ms，波幅為4.28±1.89 uV，經配對t檢驗潛伏期和波幅在兩種狀態下無顯著差異；男性在閱讀狀態下MMN潛伏期為150.48±19.57 ms，波幅為3.75±1.27 uV，在集中註意力狀態下MMN潛伏期為144.81±15.42 ms，波幅為3.99±1.34 uV，經配對t檢驗潛伏期和波幅在兩種狀態下無顯著差異；經獨立樣本t檢驗，男女在上述兩種狀態下MMN波幅和潛伏期均無顯著差異。結論正常青年男女均能引齣MMN波形，男女之間MMN檢查的波幅和潛伏期無差異，閱讀狀態和集中註意力狀態對MMN檢查的波幅和潛伏期無影響。
목적：탐토실필배부파（mismatch negativity，MMN）검사재정상청년인중적특점，병분석열독상태화집중주의력시MMN검사적결과유무차이。방법대12례청년녀성(년령29-31y，평균30.08y)화18례청년남성(년령27-34y，평균30.22y)행MMN검사，소유수시자균행은성뇌간반응（ABR）역치검사，학정ABR역치，MMN검사재수시자재열독상태화집중주의력상태시분별검측，채용oddball자격방식，급여단순음자격，편차자격성위2000Hz，개솔위20%，표준자격위1000 Hz，개솔위80%，자격빈솔위1.1차/s，자격성강도위ABR역상50dB nHL；관찰MMN잠복기급파폭적특점。결과소유수시자ABR역치균≤25 dB nHL。매례수시자균가인출MMN파형，녀성재열독상태하MMN잠복기위159.57±20.64 ms，파폭위3.82±1.38 uV，재집중주의력상태하MMN잠복기위155.96±17.51 ms，파폭위4.28±1.89 uV，경배대t검험잠복기화파폭재량충상태하무현저차이；남성재열독상태하MMN잠복기위150.48±19.57 ms，파폭위3.75±1.27 uV，재집중주의력상태하MMN잠복기위144.81±15.42 ms，파폭위3.99±1.34 uV，경배대t검험잠복기화파폭재량충상태하무현저차이；경독립양본t검험，남녀재상술량충상태하MMN파폭화잠복기균무현저차이。결론정상청년남녀균능인출MMN파형，남녀지간MMN검사적파폭화잠복기무차이，열독상태화집중주의력상태대MMN검사적파폭화잠복기무영향。
Objective To investigate the characteristics of mismatch negativity (MMN) in normal young people, and ef-fects of status of attention on MMN results. Methods MMN tests were performed on 12 young females (age 29-31years, aver-age 30.08 years) and 18 young males (age 27-34 years, average 30.22 years). In all cases, acoustic brainstem responses (ABR) were tested first so as to identify the ABR threshold. MMN were tested under the status of reading or concentrating. The odd-ball model was used in MMN testing, with brief pure tones used as the stimulus. The deviation frequency was 2000 Hz with a rate of 20%, and the standard frequency was 1000 Hz with a rate of 80%. The stimulus was delivered at 50 dB above the ABR threshold at a rate of 1.1/sec. The latency and amplitude of MMN in each group and under different attention status were analyzed. Results In all cases, ABR thresholds were≤25 dB nHL, and MMN was successfully induced. In the female group, the latency of MMN was 159.57 ± 20.64 ms with an average amplitude of 3.82 ± 1.38 uV when reading, and 155.96 ± 17.51 ms with an average amplitude of 4.28±1.89 uV when concentrating, showing no statistically significant difference on paired-t test. In the male group, the latency of MMN was 150.48 ± 19.57 ms with an average amplitude of 3.75 ± 1.27 uV when reading, and 144.81±15.42 ms with an average amplitude of 3.99±1.34 uV when concentrating, again showing no statistically significant dif-ference by paired t-test. By independent t-test, the latency and the amplitude differences were not statistically significant be-tween the female and male groups under either attention status. Conclusion MMN can be easily induced in normal young peo-ple, with no significant differences in latency or amplitude between males and females. Status of attention does not affect the re-sults of MMN test.
