CAJ | 학술논문

目的：应用低频振幅分析方法来观察长期右侧感音神经性耳聋患者静息态脑功能磁共振的改变。方法采集19例中重度右侧感音神经性耳聋患者以及20名正常听力志愿者的静息态磁共振血氧水平依赖（blood oxygenation level dependent，BOLD）数据采集，对BOLD数据进行后处理以获得低频振幅波动（amplitude of low-frequency fluctua-tion，ALFF）图像，并比较两组间ALFF信号的差异性。结果右侧耳聋组较正常听力对照组ALFF增加且差异具有统计学意义（P＜0.05，AlphaSim校正）的脑区包括在双侧颞上中回（双侧颞横回与双侧颞极）、双侧岛叶、双侧钩回、右海马旁回以及小脑前叶。右侧耳聋组较正常听力对照组ALFF减低且差异具有统计学意义（P＜0.05，AlphaSim校正）的脑区包括右侧颞中回后部。结论右侧感音神经性耳聋患者相关脑区的脑功能活动水平与正常听力人群的不同提示了耳聋后脑代偿性功能改变的存在。
목적：응용저빈진폭분석방법래관찰장기우측감음신경성이롱환자정식태뇌공능자공진적개변。방법채집19례중중도우측감음신경성이롱환자이급20명정상은력지원자적정식태자공진혈양수평의뢰（blood oxygenation level dependent，BOLD）수거채집，대BOLD수거진행후처리이획득저빈진폭파동（amplitude of low-frequency fluctua-tion，ALFF）도상，병비교량조간ALFF신호적차이성。결과우측이롱조교정상은력대조조ALFF증가차차이구유통계학의의（P＜0.05，AlphaSim교정）적뇌구포괄재쌍측섭상중회（쌍측섭횡회여쌍측섭겁）、쌍측도협、쌍측구회、우해마방회이급소뇌전협。우측이롱조교정상은력대조조ALFF감저차차이구유통계학의의（P＜0.05，AlphaSim교정）적뇌구포괄우측섭중회후부。결론우측감음신경성이롱환자상관뇌구적뇌공능활동수평여정상은력인군적불동제시료이롱후뇌대상성공능개변적존재。
Objective To investigate the change of amplitude of low-frequency fluctuation (ALFF) in resting-state func-tional magnetic resonance imaging (fMRI) in patients with long-term right side sensorineural hearing loss (SNHL). Methods Resting-state fMRI data were collected from 20 patients with long-term right side sensorineural hearing loss and 20 normal subjects. Using these data, the ALFF were mapped following post-BOLD processing and compared between the SNHL and nor-mal groups. Results In the SNHL group, the ALFF showed a significant increase in bilateral superior and middle temporal gy-ri, insular lobes, uncinate gyri, right parahippocampal gyri and anterior lobe of cerebellum, and a decrease in the posterior part of right middle temporal gyrus. Conclusion The activation changes in relevant brain regions of patients with right side SNHL indicate the potential mechanisms of the brain function remodeling.