CAJ | 학술논문

目的：观察益气活血化瘀方配合化疗治疗晚期乳腺癌的临床疗效。方法：将54例复发转移性晚期乳腺癌患者随机分为两组，治疗组27例，采用自拟益气活血化瘀方配合FAC方案治疗，对照组27例，单纯应用FAC方案治疗。两组均于4周期化疗后评定疗效，分别观察近期疗效、生活质量、不良反应发生情况及免疫学指标、肿瘤标志物等变化。结果：入组54例病例，无脱落病例，总有效率治疗组70．37％，对照组40．74％，两组比较差异有统计学意义（ P＜0．05）；生存质量改善情况，治疗组和对照组KPS评分提高稳定率分别为92．59％，66．67％，两组比较，差异显著（P＜0．05）；治疗组治疗过程中白细胞、血小板、血红蛋白下降和恶心呕吐、神经毒性及心电图改变的发生均明显低于对照组，两组比较差异具有统计学意义（P＜0．05）；免疫学指标变化，治疗组CD3＋，CD4＋及NK细胞活性明显升高，CD8＋明显降低，对照组患者治疗后CD3＋、CD4＋细胞活性明显降低，差异具有统计学意义（ P＜0．05）；两组治疗后CEA、CA153与本组治疗前及两组治疗后比较差异均有统计学意义（ P＜0．05）。结论：益气活血化瘀法联合化疗治疗晚期乳腺癌能控制病情发展，提高患者生活质量，减轻化疗的不良反应，提高细胞免疫功能，具有较好的疗效。
목적：관찰익기활혈화어방배합화료치료만기유선암적림상료효。방법：장54례복발전이성만기유선암환자수궤분위량조，치료조27례，채용자의익기활혈화어방배합FAC방안치료，대조조27례，단순응용FAC방안치료。량조균우4주기화료후평정료효，분별관찰근기료효、생활질량、불량반응발생정황급면역학지표、종류표지물등변화。결과：입조54례병례，무탈락병례，총유효솔치료조70．37％，대조조40．74％，량조비교차이유통계학의의（ P＜0．05）；생존질량개선정황，치료조화대조조KPS평분제고은정솔분별위92．59％，66．67％，량조비교，차이현저（P＜0．05）；치료조치료과정중백세포、혈소판、혈홍단백하강화악심구토、신경독성급심전도개변적발생균명현저우대조조，량조비교차이구유통계학의의（P＜0．05）；면역학지표변화，치료조CD3＋，CD4＋급NK세포활성명현승고，CD8＋명현강저，대조조환자치료후CD3＋、CD4＋세포활성명현강저，차이구유통계학의의（ P＜0．05）；량조치료후CEA、CA153여본조치료전급량조치료후비교차이균유통계학의의（ P＜0．05）。결론：익기활혈화어법연합화료치료만기유선암능공제병정발전，제고환자생활질량，감경화료적불량반응，제고세포면역공능，구유교호적료효。
Objective:To observe the clinical effect for Yiqi Huoxue Huayu method combined with chemotherapy on ad -vanced breast cancer .Methods:Select 54 patients with advanced breast cancer and they were randomly divided into two groups .27 patients in treatment group were administered with “FAC chemotherapy combined with Chinese herbs”;27 patients in control group were with “FAC chemotherapy”.Observe the changes with tumor size , KPS, toxic side effects ,immunology indexes and the values of CEA and CA 153 between groups after four cycles of chemotherapy .Results:The effective rate in the treatment group was 70.37%;the control group was 40.74%, and there was a significant difference ( P<0 .05 ) .The KPS score increase stable rate of treatment group and the control group were respectively 92 .59%and 66.67%, and there was a significant difference (P<0.05).In treatment group, the incidences of the classes of leuko-cyte, platelet and hemoglobin degression , nausea and vomiting , neurotoxicity and ECG changes were significantly lower than those of the control group (P<0.05).After treatment,the immune indexes of CD3 +,CD4 +and NK cells were sig-nificantly increased and the immune indexes of CD8+was decreased in treatment group, and in control group,the im-mune indexes of CD3 +, CD4 + were significantly decreased .By comparison, those differences were significant ( P <0.05 ) .There were also differences between two groups in CEA and CA 15-3 after treatment ( P<0 .05 ) .Conclusion:Traditional Chinese medicine method with Yiqi Huoxue Huayu method can control the progress of advanced breast canc -er, raise life quality, alleviate the side effect of chemotherapy and improve immune function .