CAJ | 학술논문

目的：观察扶正解毒法干预宫颈高危型人乳头瘤病毒（简称HR-HPV）感染的临床疗效及患者体内血清IL-6的变化，探讨扶正解毒法干预宫颈HR-HPV感染的临床价值及作用机制。方法：将宫颈高危型人乳头状病毒感染患者120例随机分成中药联合组（口服扶正解毒汤联合外用清毒散），单纯中药上药组和西药上药组（α-干扰素），比较三组治疗前后症状、体征积分，HR-HPV病毒载量及血清IL-6的变化。结果：治疗后中药联合组分别与对照组中药上药组、西药上药组比较，症状、体征积分下降更明显，说明中药联合组能明显改善患者症状、体征评分，且优于对照组；治疗后中药联合组与对照组中药上药组、西药上药组比较，病毒载量下降更快，差异有统计学意义（P＜0．05）。说明中药联合组能显著降低HPV载量值，且明显优于对照组中药上药组和西药上药组；三组治疗前血清IL-6差异无统计学意义（P＞0．05），治疗后中药联合组血清IL-6下降明显，而中药上药组和西药上药组无明显变化，差异有统计学意义（P＜0．05）。结论：中药扶正解毒法能有效治疗宫颈高危型人乳头状病毒感染，提高机体免疫功能，阻断宫颈疾病进展。
목적：관찰부정해독법간예궁경고위형인유두류병독（간칭HR-HPV）감염적림상료효급환자체내혈청IL-6적변화，탐토부정해독법간예궁경HR-HPV감염적림상개치급작용궤제。방법：장궁경고위형인유두상병독감염환자120례수궤분성중약연합조（구복부정해독탕연합외용청독산），단순중약상약조화서약상약조（α-간우소），비교삼조치료전후증상、체정적분，HR-HPV병독재량급혈청IL-6적변화。결과：치료후중약연합조분별여대조조중약상약조、서약상약조비교，증상、체정적분하강경명현，설명중약연합조능명현개선환자증상、체정평분，차우우대조조；치료후중약연합조여대조조중약상약조、서약상약조비교，병독재량하강경쾌，차이유통계학의의（P＜0．05）。설명중약연합조능현저강저HPV재량치，차명현우우대조조중약상약조화서약상약조；삼조치료전혈청IL-6차이무통계학의의（P＞0．05），치료후중약연합조혈청IL-6하강명현，이중약상약조화서약상약조무명현변화，차이유통계학의의（P＜0．05）。결론：중약부정해독법능유효치료궁경고위형인유두상병독감염，제고궤체면역공능，조단궁경질병진전。
Objective: To study Fuzheng Jiedu therapy in the treatment of cervical high -risk human papilloma virus (HR-HPV) infection and changes of serum IL -6.Discuss the clinical value and action mechanism of Fuzheng Jiedu therapy in the treatment of cervical HR -HPV.Methods:According to the random method ,120 cases of cervical HR-HPV infection patients were divided into three groups : Chinese Medication combination group ( taking orally with Fuzheng Jiedu soup and external use of Xiaodu powder ) , Chinese medication external use group , western medication (interferon-alpha) external use group.Change of the symptom,the score of symptom,the viral loads of HR-HPV,the serum IL-6 were compared among three groups .Results: After treatment , the Chinese medication combination group had an obviously better effect than other two control groups ,the Chinese medication combination group ’ s viral loads of HR-HPV declined faster than those in other two control goups , and there was a significant difference among three groups ( P<0 .05 ) .Before treatment , the serum IL-6 value of the three groups had no significantly statistical difference (P>0.05).After treatment, the Chinese medication combination group’s serum IL-6 value decreased significantly, the serum IL-6 value of other two control groups had no obvious change ,and there was a significant difference among three groups ( P<0 .05 ) .Conclusion:Fuzheng Jiedu therapy has an obvious effect in the treatment of cervical high -risk human papilloma virus(HR-HPV),and can improve the immune function of organism and block the progress of the cervical virus.