CAJ | 학술논문

以对羟基苯甲酸（PHB）和乙酸酐（Ac2 O）为原料，醋酸（HAc）为溶剂，考察浓硫酸和杂环化合物催化合成4-乙酰氧基苯甲酸（PABA），反应物配比为羟基苯甲酸∶乙酸酐∶醋酸＝1∶1．05∶0．5，确定最佳催化剂加入量、反应时间和反应温度。结果表明，浓硫酸为催化剂时，最佳反应时间2 h，反应温度100℃，催化剂加入量为 PHB质量的4％，产率67％；杂环化合物P为催化剂时，最佳反应温度80℃，反应时间2 h，催化剂加入量为PHB质量的0．3％，产率99．8％。杂环化合物比浓硫酸对 PABA合成有更好的催化活性，反应条件温和，具有较好的工业化应用前景。
이대간기분갑산（PHB）화을산항（Ac2 O）위원료，작산（HAc）위용제，고찰농류산화잡배화합물최화합성4-을선양기분갑산（PABA），반응물배비위간기분갑산∶을산항∶작산＝1∶1．05∶0．5，학정최가최화제가입량、반응시간화반응온도。결과표명，농류산위최화제시，최가반응시간2 h，반응온도100℃，최화제가입량위 PHB질량적4％，산솔67％；잡배화합물P위최화제시，최가반응온도80℃，반응시간2 h，최화제가입량위PHB질량적0．3％，산솔99．8％。잡배화합물비농류산대 PABA합성유경호적최화활성，반응조건온화，구유교호적공업화응용전경。
In this paper the efficiency of two catalysts,concentrated sulfuric acid and heterocyclic compound P,has been compared during the synthesis of p-Acetoxybenzoic acid (PABA)with p-Hydroxybenzoic acid (PHB) and acetic anhydride as raw materials.Thus the added amount of catalyst,the reaction time and the reaction tem-perature were optimized for the reaction mixture of p-hydroxy benzoic acid,acetic anhydride and acetic acid with a loading ratio of 1∶1∶0.5.It has been found that the most suitable reaction time,reaction temperature,catalyst ad-dition (respect to PHB weight)and productivity of PABA could be 2 h,100 ℃,4%,67% or 2 h,80 ℃, 0.3%,99.8% when using concentrated sulfuric acid or heterocyclic compound P as catalyst,respectively.There-fore,heterocyclic compound P showed a better catalytic activity compared to concentrated sulfuric acid,with which the synthesis of PABA could be carried out under a relatively loose reaction conditions,and promised a great appli-cation foreground.