CAJ | 학술논문

目的：利用文献计量学的方法对鲍曼不动杆菌（Ab）耐药机制的相关文献进行统计分析，以便指导临床合理用药。方法：检索PubMed、Embase、SCI英文数据库，对鲍曼不动杆菌耐药机制的相关文献进行汇总，对纳入研究的文献年份分布、作者、语种、文章类型、药物类型等进行统计分析。结果：纳入研究的文献共计2061篇，文献数量呈逐年递增趋势。其中，研究最多的药物是亚胺培南；对于碳青霉烯类抗菌药物的耐药机制研究较多。关于耐药机制的研究，分别从基因或者蛋白等角度进行阐明。从文献发表期刊分析，微生物和抗感染领域对Ab耐药机制的关注度最高，其次为药理、药学领域。结论：碳青霉烯类耐药仍是鲍曼不动杆菌耐药研究领域的重点之一，其主要的耐药机制是产生水解碳青霉烯的β-内酰胺酶-OXA酶和金属β-内酰胺酶（MBL）。
목적：이용문헌계량학적방법대포만불동간균（Ab）내약궤제적상관문헌진행통계분석，이편지도림상합리용약。방법：검색PubMed、Embase、SCI영문수거고，대포만불동간균내약궤제적상관문헌진행회총，대납입연구적문헌년빈분포、작자、어충、문장류형、약물류형등진행통계분석。결과：납입연구적문헌공계2061편，문헌수량정축년체증추세。기중，연구최다적약물시아알배남；대우탄청매희류항균약물적내약궤제연구교다。관우내약궤제적연구，분별종기인혹자단백등각도진행천명。종문헌발표기간분석，미생물화항감염영역대Ab내약궤제적관주도최고，기차위약리、약학영역。결론：탄청매희류내약잉시포만불동간균내약연구영역적중점지일，기주요적내약궤제시산생수해탄청매희적β-내선알매-OXA매화금속β-내선알매（MBL）。
Objective: To investigate resistance mechanisms of Acinetobacter baumannii by bibliometric method. Methods: All literatures searched in PubMed, Embase and SCI database with the key words of Acinetobacter baumannii, drug resistance were collected. The amount of literatures, publication date, authors, languages, types of papers and antibiotic were analyzed. Results: A total of 2061 literature papers were searched from three databases. The amount of literatures increased year by year. Imipenem was the most studied antibiotic. The most researches on resistance mechanisms of Acinetobacter baumannii focused on that of carbapenem drugs, which were clariifed from the perspective of genes or proteins. Resistance mechanisms were mainly studied in the ifeld of microbiology and anti-infection. Conclusion: Carbapenem resistance was always one focus of the drug resistance of Acinetobacter baumannii. The most prevalent mechanism of carbapenem resistance in Acinetobacter baumannii is enzymatic degradation for carbapenemases, namely OXA type and metallo-β-lactamases (MBL).