CAJ | 학술논문

目的：探讨2012年象山县不良反应发生的规律和特点，为临床合理用药提供参考。方法：采用Pareto最优分析，对2012年填写上报的513例ADR报告进行整理，从患者年龄、给药途径、抗菌药物品种、严重和新的ADR及相关临床表现等方面进行分析和归纳。结果：513例ADR报告中，男性203例（39.6%），女性310例（60.4%），发生ADR患者主要年龄段在30岁以上，尤其是60岁以上的老年人是高发群体；主要给药途径为静脉滴注；涉及药物种类主要为抗菌药物；发生严重的和新的ADR共271例（52.8%）。结论：应加强对患者的用药监护，做到个体化给药，以减少ADR的发生，确保临床用药安全、有效。
목적：탐토2012년상산현불량반응발생적규률화특점，위림상합리용약제공삼고。방법：채용Pareto최우분석，대2012년전사상보적513례ADR보고진행정리，종환자년령、급약도경、항균약물품충、엄중화신적ADR급상관림상표현등방면진행분석화귀납。결과：513례ADR보고중，남성203례（39.6%），녀성310례（60.4%），발생ADR환자주요년령단재30세이상，우기시60세이상적노년인시고발군체；주요급약도경위정맥적주；섭급약물충류주요위항균약물；발생엄중적화신적ADR공271례（52.8%）。결론：응가강대환자적용약감호，주도개체화급약，이감소ADR적발생，학보림상용약안전、유효。
Objective: To investigate the characteristics of adverse drug reaction of Xiangshan country in 2012 for providing references about rational drug use. Methods:The Pareto optimal analysis was adopted to analyze the ADRs in respect of the patient's age, route of administration, antimicrobial varieties, the severe and new ADRs as well as drug-related clinical manifestations. Results: Among the 513 ADR cases, 203 cases (39.6%) were male and 310 cases (60.4%) were female. Most cases were more than 30 years old. The patients over 60 years old were at high risk of ADRs. The main route of administration was intravenous drip. Antibacterials were mostly involved in 513 ADR reports. A total of 271 cases (52.8%) were severe and new ADRs. Conclusion:Pharmaceutical care and individual regime should be strengthened to improve rational drug use and reduce the occurrence of ADRs.