CAJ | 학술논문

目的：比较国产硝苯地平缓释片、马来酸依那普利片和富马酸比索洛尔片对Ⅰ级高血压患者的降压效果。方法：182例患者随机分为3组：硝苯地平缓释片组（20 mg，62例）、依那普利组（5 mg，60例）与比索洛尔组（5 mg，60例），经过2周安慰剂导入期进入临床观察阶段，观察期4周。每组药物均为每日一次服用，并进行24 h动态心电、动态血压同时监测。结果：3种药物均能显著降低血压，硝苯地平缓释片、依那普利和比索洛尔组与治疗前相比，分别降低了（10±13）mm Hg，（19±11）mm Hg和（7±18）mm Hg；比索洛尔组降低24 h平均收缩压及白天平均舒张压的幅度大于硝苯地平缓释片组和依那普利组。结论：3种降压药每日一次服用，对Ⅰ级高血压患者均有明显降压疗效，且比索洛尔组疗效优于硝苯地平缓释片组及依那普利组。
목적：비교국산초분지평완석편、마래산의나보리편화부마산비색락이편대Ⅰ급고혈압환자적강압효과。방법：182례환자수궤분위3조：초분지평완석편조（20 mg，62례）、의나보리조（5 mg，60례）여비색락이조（5 mg，60례），경과2주안위제도입기진입림상관찰계단，관찰기4주。매조약물균위매일일차복용，병진행24 h동태심전、동태혈압동시감측。결과：3충약물균능현저강저혈압，초분지평완석편、의나보리화비색락이조여치료전상비，분별강저료（10±13）mm Hg，（19±11）mm Hg화（7±18）mm Hg；비색락이조강저24 h평균수축압급백천평균서장압적폭도대우초분지평완석편조화의나보리조。결론：3충강압약매일일차복용，대Ⅰ급고혈압환자균유명현강압료효，차비색락이조료효우우초분지평완석편조급의나보리조。
Objective: To observe the hypotensive effects of nifedipine sustained-release tablets, enalapril maleate tablets and bisoprolol fumarate tablets in patients withⅠgrade hypertension. Methods:A total of 182 patients withⅠgrade hypertension were randomly divided into three groups: nifedipine group (62 patients taking nifedipine sustained-release tablets 20 mg daily), enalapril group (60 patients taking enalapril 5 mg daily) and bisoprolol group (60 patients taking bisoprolol 5 mg daily). All patients entered 4-week clinical observation with 24-hour Holter and ambulatory blood pressure monitoring after 2-week placebo induce. Results:The three drugs signiifcantly reduced casual blood pressures. After administration the blood pressure of nifedipine group, enalapril group and bisoprolol group reduced (10 ± 13) mm Hg, (19 ± 11) mm Hg and (7 ± 18) mm Hg respectively. Bisoprolol showed more hypotensive effect on 24-hour mean systolic blood pressure and daytime mean diastolic blood pressure than nifedipine and enalapril. Conclusion:Administration of nifedipine sustained-release tablets 20 mg daily, enalapril 5 mg daily and bisoprolol 5 mg daily showed signiifcant hypotensive effect. Bisoprolol was better than nifedipine and enalapril.