中国小儿血液与肿瘤杂志
中國小兒血液與腫瘤雜誌
중국소인혈액여종류잡지
JOURNAL OF CHINA PEDIATRIC BLOOD AND CANCER
2014年
3期
147-150
,共4页
赵贝贝%李捷%李祯萍%朱明清%耿美菊%柴忆欢%何海龙
趙貝貝%李捷%李禎萍%硃明清%耿美菊%柴憶歡%何海龍
조패패%리첩%리정평%주명청%경미국%시억환%하해룡
微小残留病%急性淋巴细胞白血病%B细胞%儿童%无事件生存率
微小殘留病%急性淋巴細胞白血病%B細胞%兒童%無事件生存率
미소잔류병%급성림파세포백혈병%B세포%인동%무사건생존솔
Minimal residual disease%Acute lymphoblastic leukemia%B-Lineage%Children%Event-free survival
目的:对88例儿童急性B淋巴细胞白血病(B-ALL)治疗的长期随访结果进行分析,探讨微小残留病(MRD)监测下儿童B-ALL的无事件生存率(EFS )。方法回顾性分析2005年1月-2008年5月接受儿童ALL诊疗建议(第三次修订草案)治疗的88例B-ALL患儿,应用流式细胞术(FCM)检测MRD,采用Kaplan-Meier方法评估患儿EFS,各临床危险度分组间患儿EFS 差异用Log-rank检验。结果88例患儿骨髓完全缓解(CR)率为97.7%,2年、3年、4年、5年 EFS 率分别为87.5%、86.4%、81.8%、77.2%,标危、中危、高危5年EFS率分别为86.2%、84.6%、63.1%。5例死亡,9例复发(10.5%),复发中位时间为23(3~59)个月。结论采用儿童ALL诊疗建议(第三次修订草案)治疗CR率较高,在MRD监测下指导治疗,总体上B-ALL患儿的5年EFS提高。
目的:對88例兒童急性B淋巴細胞白血病(B-ALL)治療的長期隨訪結果進行分析,探討微小殘留病(MRD)鑑測下兒童B-ALL的無事件生存率(EFS )。方法迴顧性分析2005年1月-2008年5月接受兒童ALL診療建議(第三次脩訂草案)治療的88例B-ALL患兒,應用流式細胞術(FCM)檢測MRD,採用Kaplan-Meier方法評估患兒EFS,各臨床危險度分組間患兒EFS 差異用Log-rank檢驗。結果88例患兒骨髓完全緩解(CR)率為97.7%,2年、3年、4年、5年 EFS 率分彆為87.5%、86.4%、81.8%、77.2%,標危、中危、高危5年EFS率分彆為86.2%、84.6%、63.1%。5例死亡,9例複髮(10.5%),複髮中位時間為23(3~59)箇月。結論採用兒童ALL診療建議(第三次脩訂草案)治療CR率較高,在MRD鑑測下指導治療,總體上B-ALL患兒的5年EFS提高。
목적:대88례인동급성B림파세포백혈병(B-ALL)치료적장기수방결과진행분석,탐토미소잔류병(MRD)감측하인동B-ALL적무사건생존솔(EFS )。방법회고성분석2005년1월-2008년5월접수인동ALL진료건의(제삼차수정초안)치료적88례B-ALL환인,응용류식세포술(FCM)검측MRD,채용Kaplan-Meier방법평고환인EFS,각림상위험도분조간환인EFS 차이용Log-rank검험。결과88례환인골수완전완해(CR)솔위97.7%,2년、3년、4년、5년 EFS 솔분별위87.5%、86.4%、81.8%、77.2%,표위、중위、고위5년EFS솔분별위86.2%、84.6%、63.1%。5례사망,9례복발(10.5%),복발중위시간위23(3~59)개월。결론채용인동ALL진료건의(제삼차수정초안)치료CR솔교고,재MRD감측하지도치료,총체상B-ALL환인적5년EFS제고。
Objective To analyse the treatment outcome of 88 childhood B-Lineage acute lymphoblastic leukemia (B-ALL )patients,and explore how to improve the event-free survival (EFS ) rate in ALL. Methods 88 children diagnosed as ALL from January 2005 to May 2008 were analyzed retrospectively.All entered the Children ALL therapy protocol (The third time revised)clinical trial and minimal residual disease (MRD).Kaplan-Meier method was used to estimate survival rates and differences were compared with the 2-side log-rank test,statistics was done by SPSS.Results Out of the 88 patients,86 (97.7%)attained complete remisson (CR).The overall EFS rate at 5 years was 77.2%.The EFS rates at 5 years in low-risk (LR), median-risk (MR)and high-risk (HR)groups were 86.2%,84.6%,63.1%,respectively (P <0.05 ). Relapses occurred in 9 patients (10.5%)in median time of 23 months.Conclusions The early response to improve CR was an important independent prognostic factor.Children ALL therapy protocol (The third time revised)decreased tbe rate of the relapsed and improved the long-term event-free survival rate with MRD.