中国小儿血液与肿瘤杂志
中國小兒血液與腫瘤雜誌
중국소인혈액여종류잡지
JOURNAL OF CHINA PEDIATRIC BLOOD AND CANCER
2014年
3期
126-128
,共3页
王懿林%赵洪祥%尹莎莎%葛云鹏%战玉助
王懿林%趙洪祥%尹莎莎%葛雲鵬%戰玉助
왕의림%조홍상%윤사사%갈운붕%전옥조
抗心磷脂抗体%儿童%紫癜,过敏性%抗磷脂综合征
抗心燐脂抗體%兒童%紫癜,過敏性%抗燐脂綜閤徵
항심린지항체%인동%자전,과민성%항린지종합정
Anti-cardiolipin antibodies%Childhood%Henoch-Scho¨nlein purpura%Antiphospholipid syndrome
目的：探讨抗心磷脂抗体（anticardiolipin，ACA）与儿童过敏性紫癜（Henoch-scho¨nlein purpura，HSP）的关系。方法采用酶联免疫吸附试验（ELISA）对91例急性期HSP患儿（HSP组）和30例健康体检儿童（对照组）的血清进行IgG型ACA（IgG-ACA）和IgM型ACA（IgM-ACA）检测，并对两组ACA阳性率进行统计学比较。结果91例HSP患儿中有16例ACA阳性，其中IgM-ACA阳性13例，IgG-ACA阳性3例，总阳性率占17.6％，且均无抗磷脂综合征（APS）表现；而健康体检儿未检出ACA阳性者。经Fisher精确概率检验，差异有显著性（χ2＝6.078，P＜0.05）。HSP组中50例伴有腹痛的患儿中其13例ACA阳性，阳性率为26.0％；而41例不伴腹痛的患儿中仅3例ACA阳性，阳性率为7.3％，经χ2检验，差异有显著性（χ2＝5.426，P＜0.05）。26例肾脏受损者中ACA阳性4例；65例无肾脏受损者中ACA阳性12例，经χ2检验，差异无显著性（χ2＝0.002，P＞0.05）。结论 ACA可能与儿童HSP发病及腹痛症状有关、与HSP肾损害无关；APS可能与儿童HSP无关。
目的：探討抗心燐脂抗體（anticardiolipin，ACA）與兒童過敏性紫癜（Henoch-scho¨nlein purpura，HSP）的關繫。方法採用酶聯免疫吸附試驗（ELISA）對91例急性期HSP患兒（HSP組）和30例健康體檢兒童（對照組）的血清進行IgG型ACA（IgG-ACA）和IgM型ACA（IgM-ACA）檢測，併對兩組ACA暘性率進行統計學比較。結果91例HSP患兒中有16例ACA暘性，其中IgM-ACA暘性13例，IgG-ACA暘性3例，總暘性率佔17.6％，且均無抗燐脂綜閤徵（APS）錶現；而健康體檢兒未檢齣ACA暘性者。經Fisher精確概率檢驗，差異有顯著性（χ2＝6.078，P＜0.05）。HSP組中50例伴有腹痛的患兒中其13例ACA暘性，暘性率為26.0％；而41例不伴腹痛的患兒中僅3例ACA暘性，暘性率為7.3％，經χ2檢驗，差異有顯著性（χ2＝5.426，P＜0.05）。26例腎髒受損者中ACA暘性4例；65例無腎髒受損者中ACA暘性12例，經χ2檢驗，差異無顯著性（χ2＝0.002，P＞0.05）。結論 ACA可能與兒童HSP髮病及腹痛癥狀有關、與HSP腎損害無關；APS可能與兒童HSP無關。
목적：탐토항심린지항체（anticardiolipin，ACA）여인동과민성자전（Henoch-scho¨nlein purpura，HSP）적관계。방법채용매련면역흡부시험（ELISA）대91례급성기HSP환인（HSP조）화30례건강체검인동（대조조）적혈청진행IgG형ACA（IgG-ACA）화IgM형ACA（IgM-ACA）검측，병대량조ACA양성솔진행통계학비교。결과91례HSP환인중유16례ACA양성，기중IgM-ACA양성13례，IgG-ACA양성3례，총양성솔점17.6％，차균무항린지종합정（APS）표현；이건강체검인미검출ACA양성자。경Fisher정학개솔검험，차이유현저성（χ2＝6.078，P＜0.05）。HSP조중50례반유복통적환인중기13례ACA양성，양성솔위26.0％；이41례불반복통적환인중부3례ACA양성，양성솔위7.3％，경χ2검험，차이유현저성（χ2＝5.426，P＜0.05）。26례신장수손자중ACA양성4례；65례무신장수손자중ACA양성12례，경χ2검험，차이무현저성（χ2＝0.002，P＞0.05）。결론 ACA가능여인동HSP발병급복통증상유관、여HSP신손해무관；APS가능여인동HSP무관。
Objective To discuss the relation between anti-cardiolipin antibodies (ACA ) and Henoch-Scho¨nlein purpura(HSP)in children.Methods The levels of serum IgG-ACA and IgM-ACA in 91 children with Henoch Scho¨nlein purpura in acute stage (HSP group)and 30 healthy cases (control group) were tested with enzyme-linked immunosorbent assay (ELISA ). Statistical analysis were performed to compare the differences of serum ACA levels between two groups.Results 16 patients in HSP group were positive of serum levels of ACA,with 13 of IgM-ACA and 3 of IgG-ACA respectively, and no one manifested signs of antiphospholipid syndrome.None of healthy cases in control group were positive of ACA,the overall positive rate of ACA in HSP group was 17.6% and statistically different (Fisher exact probability test,χ2 =6.078,P<0.05).In HSP group,13 cases out of 50 patients with abdominal pain were positive of ACA and the positive rate was 26.0%;only 3 cases among 41 patients without abdominal pain were positive of ACA and the positive rate was 7 .3%.The difference was statistically significant(χ2 =5.426,P<0.05).4 cases out of 26 patients of Henoch-Scho¨nlein purpura with renal damage were positive of ACA.Among 65 patients without renal damage,12 cases were positive of ACA and the difference was not statistically significant(χ2 =0.002,P>0.05).Conclusions Serum ACA may have a connection with pathogenesis of childhood HSP and abdominal pain,but not correlate with renal damage.Antiphospholipid syndrome probably has nothing to do with childhood HSP.
