CAJ | 학술논문

目的：研究脑小血管患者功能性影像学特征并探讨其与患者认知功能损害的相关性。方法：脑小血管病患者15例作为观察组，健康受试者15名作为对照组，采用简易智力状况检查法（MMSE ）、蒙特利尔认知评估（Mo-CA）、美国国立卫生院神经功能缺损评分（NIHSS）评定患者认知功能损害程度；采用磁共振平扫及多模态磁共振成像技术观察平均弥散系数（ADC ）和各向异性值（FA ）以及脑内微出血数目与患者认知功能损害之间的关系。结果：观察组MMSE、MoCA评分明显低于对照组，而NIHSS评分高于对照组（均 P＜0．01）。观察组额颞叶、顶叶、基底节区FA值明显低于对照组（P＜0．05），ADC值明显高于对照组（P＜0．05）。观察组脑内微出血数目明显高于对照组（P＜0．01）。脑小血管患者脑内微出血数目及额颞叶 FA、DCaverage值与认知功能损害密切相关（P＜0．05）。结论：脑小血管病患者额颞叶白质损伤程度以及微出血数目与认知功能损害之间密切相关。
목적：연구뇌소혈관환자공능성영상학특정병탐토기여환자인지공능손해적상관성。방법：뇌소혈관병환자15례작위관찰조，건강수시자15명작위대조조，채용간역지력상황검사법（MMSE ）、몽특리이인지평고（Mo-CA）、미국국립위생원신경공능결손평분（NIHSS）평정환자인지공능손해정도；채용자공진평소급다모태자공진성상기술관찰평균미산계수（ADC ）화각향이성치（FA ）이급뇌내미출혈수목여환자인지공능손해지간적관계。결과：관찰조MMSE、MoCA평분명현저우대조조，이NIHSS평분고우대조조（균 P＜0．01）。관찰조액섭협、정협、기저절구FA치명현저우대조조（P＜0．05），ADC치명현고우대조조（P＜0．05）。관찰조뇌내미출혈수목명현고우대조조（P＜0．01）。뇌소혈관환자뇌내미출혈수목급액섭협 FA、DCaverage치여인지공능손해밀절상관（P＜0．05）。결론：뇌소혈관병환자액섭협백질손상정도이급미출혈수목여인지공능손해지간밀절상관。
Objective :To investigate the relationship between functional features of multimode MR scan and cogni-tive impairment in patients with cerebral small vessel disease .Methods :Fifteen cases of cerebral small vessel diseases and 15 healthy subjects were recruited as observation group and control group ,respectively .The cognitive impair-ment was evaluated using the mini-mental state examination (MMSE) ,Montreal cognitive assessment (MoCA) ,and National Institute of Health Stroke Scale (NIHSS) .The average diffusion coefficient (ADC) ,fractional anisotropy (FA) and cerebral micro bleeding were assessed using multimode MR scan .The relationship between small cerebral vessel disease and cognitive decline was also analyzed .Results :The MMSE and MoCA scores were obviously lower , and NIHSS score was higher in observation group than in control group (P<0 .01 for all) .The FA value in frontal temporal lobe ,parietal lobe and basal ganglia was obviously lower ,the ADC value and number of cerebral microb-leeding were significantly higher in observation group than in control group (P<0 .05 for all) .The number of cere-bral microbleedings ,the FA value and ADC value in frontal temporal lobe had a close relationship with the cognitive impairment (P<0 .05) .Conclusion:The number of cerebral microbleedings and the severity of white matter dam-age were strongly associated with the cognitive decline .