CAJ | 학술논문

肿瘤相关巨噬细胞（ Tumor associate macrophages ，TAMs）是肿瘤的炎症微环境与肿瘤细胞间的重要信使。它是从血液中的单核细胞演变而来，主要通过集落刺激因子（ Colony -stimulating factor ， CSF）趋化至肿瘤组织中。本文简述了TAMs通过影响血管生成和淋巴管生成，抑制免疫，调节基质，与干细胞相互作用等方面促进肿瘤的进展。分析表明靶向于TAMs的治疗策略是未来治疗肿瘤的一个新方向。
종류상관거서세포（ Tumor associate macrophages ，TAMs）시종류적염증미배경여종류세포간적중요신사。타시종혈액중적단핵세포연변이래，주요통과집락자격인자（ Colony -stimulating factor ， CSF）추화지종류조직중。본문간술료TAMs통과영향혈관생성화림파관생성，억제면역，조절기질，여간세포상호작용등방면촉진종류적진전。분석표명파향우TAMs적치료책략시미래치료종류적일개신방향。
Tumor associate macrophages ( TAMs) play a significant role in the interaction of tumor inflam-mative microenvironment and tumor cells .TAMs originate from monocytic precursors ,recruiting into tumor tissue by colony stimulating factor ( CSF) .This review summarized that TAMs promote tumor progression and metastasis though angiogenesis ,lymphogenesis , immunosuppression , matrix remodeling and affecting cancer stem cells .The article pointed that targeting TAMs is a new strategy for future tumor therapy .