CAJ | 학술논문

羊水间充质干细胞是多能的非造血祖细胞，具有自我修复及多向分化潜能，如成骨细胞、成软骨细胞及成脂肪细胞。尽管其具有高度增殖能力，但是其在体内并没有成瘤的报道，甚至多次传代后其核型也正常。 AF-MSCs对肿瘤的趋向性及其作为治疗多种肿瘤的细胞载体已经被很多研究证实。本文总结近期国内外的相关文献，就羊水间充质干细胞在肿瘤治疗中的研究进展进行综述。
양수간충질간세포시다능적비조혈조세포，구유자아수복급다향분화잠능，여성골세포、성연골세포급성지방세포。진관기구유고도증식능력，단시기재체내병몰유성류적보도，심지다차전대후기핵형야정상。 AF-MSCs대종류적추향성급기작위치료다충종류적세포재체이경피흔다연구증실。본문총결근기국내외적상관문헌，취양수간충질간세포재종류치료중적연구진전진행종술。
Amniotic fluid-derived mesenchymal stem cells(AF-MSCs)are multipotential,nonhemato-poietic progenitor cells that have an inherent ability to self -renew and to differentiate into many cell types ,inclu-ding osteoblasts,chondrocytes and adipocytes.Despite their high proliferation rate,no in vivo tumorigenicity has been reported and their karyotype was normal even after extensive expansion in culture .Several studies have dem-onstrated the inherent tumortropic properties of MSCs and their successful use as cellular vehicles of therapeutic agents for the treatment of several types of cancer .This article reviews recent articles on studying the role of amni-otic fluid-derived mesenchymal stem cells in cancer therapy .