CAJ | 학술논문

目的：探讨新生儿早期先天性梅毒的临床特点及防治方法。方法将72例诊断为先天性梅毒的新生儿，按孕母怀孕期间是否进行驱梅治疗分为治疗组和未治疗组，对临床资料进行回顾性分析。结果新生儿早期先天性梅毒的临床表现多种多样；治疗组早产、小于胎龄儿及器官损伤发生率明显低于未治疗组（P<0.05）；早期应用青霉素治疗先天性梅毒具有良好疗效。结论新生儿早期先天性梅毒多由母婴垂直传播所致，临床表现多样，孕母在孕期未治疗的先天性梅毒患儿出生后临床表现较重。新生儿科医师须提高对先天性梅毒发病的认识并给予积极的治疗，可缓解病情并显著改善预后。
목적：탐토신생인조기선천성매독적림상특점급방치방법。방법장72례진단위선천성매독적신생인，안잉모부잉기간시부진행구매치료분위치료조화미치료조，대림상자료진행회고성분석。결과신생인조기선천성매독적림상표현다충다양；치료조조산、소우태령인급기관손상발생솔명현저우미치료조（P<0.05）；조기응용청매소치료선천성매독구유량호료효。결론신생인조기선천성매독다유모영수직전파소치，림상표현다양，잉모재잉기미치료적선천성매독환인출생후림상표현교중。신생인과의사수제고대선천성매독발병적인식병급여적겁적치료，가완해병정병현저개선예후。
Objective To investigate the clinical characteristics and methods of prevention and treatment of neonatal early congenital syphilis. Methods Seventy-two neonates diagnosed with congenital syphilis were divided into a treatment group and an untreated group, according to whether they had received pregnancy syphilis therapy or not. The clinical data were analyzed retro-spectively. Results Clinical manifestations of neonatal early congenital syphilis varied. The incidence rates of premature birth, small for gestational age and organ damage in the treatment group were significantly lower than those in the untreated group (P<0.05). Early use of penicillin in treatment of early congenital syphilis had a good effect. Conclusions Neonatal early congenital syphilis is caused by the vertical transmission. Its clinical menifestations vary, and neonatal congenital syphilis untreated during pregnancy has more severe clinical manifestations. Neonatologists need to improve awareness of the incidence of congenital syphilis and give aggressive treatment, so as to alleviate the condition and significantly improve the prognosis.