传染病信息
傳染病信息
전염병신식
INFECTIOUS DISEASE INFORMATION
2014年
3期
167-169
,共3页
杨德华%易冬玲%周晓飞%张亚美
楊德華%易鼕玲%週曉飛%張亞美
양덕화%역동령%주효비%장아미
手足口病%危重症%肠道病毒属%免疫球蛋白类
手足口病%危重癥%腸道病毒屬%免疫毬蛋白類
수족구병%위중증%장도병독속%면역구단백류
hand,foot and mouth disease%critical illness%enterovirus%immunoglobulins
目的：探讨轻症和重症手足口病（hand, foot and mouth disease, HFMD）患儿血清免疫球蛋白变化与疾病进展的相关性。方法选择本院2013年6月住院的轻症和重症HFMD患儿369例，其中轻症组259例，重症组（含危重型）110例；以同期30名体检正常的健康儿童为对照组。采用免疫比浊法检测各组血清免疫球蛋白（IgA、IgG、IgM）和补体C3、C4表达水平。比较各组及重症组肠道病毒71型（enterovirus 71, EV71）感染和非EV71感染患儿、柯萨奇病毒A16（coxsackievirus A16, Cox-A16）感染和EV71感染患儿的血清免疫球蛋白表达水平。结果与对照组相比，重症组IgG、IgA和IgM水平显著升高，轻症组IgM水平显著升高；与轻症组相比，重症组IgG和IgA水平显著升高；重症组EV71感染患儿IgM水平显著高于非EV71感染患儿，其IgG和IgM水平显著高于CoxA16感染患儿；各组间补体C3、C4水平比较差异均无统计学意义。结论 HFMD患儿血清免疫球蛋白表达水平存在变化，随着病情进展，血清免疫球蛋白表达水平变化更加显著。重症患儿血清免疫球蛋白表达水平显著高于轻症患儿，重症患儿中EV71感染者较CoxA16感染者血清免疫球蛋白表达水平变化更加显著。
目的：探討輕癥和重癥手足口病（hand, foot and mouth disease, HFMD）患兒血清免疫毬蛋白變化與疾病進展的相關性。方法選擇本院2013年6月住院的輕癥和重癥HFMD患兒369例，其中輕癥組259例，重癥組（含危重型）110例；以同期30名體檢正常的健康兒童為對照組。採用免疫比濁法檢測各組血清免疫毬蛋白（IgA、IgG、IgM）和補體C3、C4錶達水平。比較各組及重癥組腸道病毒71型（enterovirus 71, EV71）感染和非EV71感染患兒、柯薩奇病毒A16（coxsackievirus A16, Cox-A16）感染和EV71感染患兒的血清免疫毬蛋白錶達水平。結果與對照組相比，重癥組IgG、IgA和IgM水平顯著升高，輕癥組IgM水平顯著升高；與輕癥組相比，重癥組IgG和IgA水平顯著升高；重癥組EV71感染患兒IgM水平顯著高于非EV71感染患兒，其IgG和IgM水平顯著高于CoxA16感染患兒；各組間補體C3、C4水平比較差異均無統計學意義。結論 HFMD患兒血清免疫毬蛋白錶達水平存在變化，隨著病情進展，血清免疫毬蛋白錶達水平變化更加顯著。重癥患兒血清免疫毬蛋白錶達水平顯著高于輕癥患兒，重癥患兒中EV71感染者較CoxA16感染者血清免疫毬蛋白錶達水平變化更加顯著。
목적：탐토경증화중증수족구병（hand, foot and mouth disease, HFMD）환인혈청면역구단백변화여질병진전적상관성。방법선택본원2013년6월주원적경증화중증HFMD환인369례，기중경증조259례，중증조（함위중형）110례；이동기30명체검정상적건강인동위대조조。채용면역비탁법검측각조혈청면역구단백（IgA、IgG、IgM）화보체C3、C4표체수평。비교각조급중증조장도병독71형（enterovirus 71, EV71）감염화비EV71감염환인、가살기병독A16（coxsackievirus A16, Cox-A16）감염화EV71감염환인적혈청면역구단백표체수평。결과여대조조상비，중증조IgG、IgA화IgM수평현저승고，경증조IgM수평현저승고；여경증조상비，중증조IgG화IgA수평현저승고；중증조EV71감염환인IgM수평현저고우비EV71감염환인，기IgG화IgM수평현저고우CoxA16감염환인；각조간보체C3、C4수평비교차이균무통계학의의。결론 HFMD환인혈청면역구단백표체수평존재변화，수착병정진전，혈청면역구단백표체수평변화경가현저。중증환인혈청면역구단백표체수평현저고우경증환인，중증환인중EV71감염자교CoxA16감염자혈청면역구단백표체수평변화경가현저。
Objective To investigate the relationship between serum immunoglobulin levels and disease progression in mild and severe children with hand, foot and mouth disease (HFMD). Methods A total of 369 HFMD children, admitted to our hospital during Jun. 2013, were divided into a mild group (n=259) and a severe group (n=110). Thirty healthy children receiving physical ex-amination were selected as controls. Immune turbidimetry assay was used to detect the levels of serum IgA, IgG, IgM, C3 and C4. Serum immunoglobulin levels were compared among the mild group, the severe group and the control group, and between the severe children with enterovirus 71 (EV71) and without EV71 infection, and between the severe children with coxsackievirus A16 (CoxA16) and EV71 infection. Results As compared with the control group, the levels of IgG, IgA and IgM of the severe group and the level of IgM of the mild group increased significantly. As compared with the mild HFMD group, the levels of IgG and IgA of severe HFMD group increased significantly. The level of IgM of the severe children with EV71 infection was significantly higher than that of the severe children without EV71 infection, and the levels of IgG and IgA of the severe children with EV71 infection were signifi-cantly higher than those of the severe children with CoxA16 infection. The levels of C3 and C4 were not significantly different among the groups. Conclusion Serum immunoglobulin levels of HFMD children change, and they change significantly with disease pro-gression. The levels of the severe HFMD children are significantly higher than those of the mild HFMD children. The levels of the severe children with EV71 infection change more significantly than those of the severe children with CoxA16 infection.
