CAJ | 학술논문

目的：分析采用血液灌流治疗急性卡马西平中毒的经验和价值。方法选择2007年5月至2013年7月就诊于西安市儿童医院重症医学科的45例误服卡马西平且入院血药浓度大于15μg/mL的患儿，将其分为血液灌流组（灌流组）24例和常规治疗组（对照组）21例，灌流组在常规治疗的基础上进行血液灌流治疗。两组患儿在治疗0、24、48、72小时测定卡马西平血药浓度。结果血液灌流组血清卡马西平浓度分别为：38．5±23．42μg/mL，17．54±5．56μg/mL，9．80±2．90μg/mL，1．20±1．03μg/mL；常规治疗组血清卡马西平浓度分别为：35．52±5．56μg/mL，30．92±5．53μg/mL，24．38±4．44μg/mL，16．52±4．23μg/mL，灌流组患儿血清卡马西平浓度在24、48、72小时较对照组低，差异有统计学意义（ t值分别为4．832，5．233，3．343，P＜0．05）。结论血液灌流对卡马西平急性中毒有明显疗效，能快速降低卡马西平浓度。
목적：분석채용혈액관류치료급성잡마서평중독적경험화개치。방법선택2007년5월지2013년7월취진우서안시인동의원중증의학과적45례오복잡마서평차입원혈약농도대우15μg/mL적환인，장기분위혈액관류조（관류조）24례화상규치료조（대조조）21례，관류조재상규치료적기출상진행혈액관류치료。량조환인재치료0、24、48、72소시측정잡마서평혈약농도。결과혈액관류조혈청잡마서평농도분별위：38．5±23．42μg/mL，17．54±5．56μg/mL，9．80±2．90μg/mL，1．20±1．03μg/mL；상규치료조혈청잡마서평농도분별위：35．52±5．56μg/mL，30．92±5．53μg/mL，24．38±4．44μg/mL，16．52±4．23μg/mL，관류조환인혈청잡마서평농도재24、48、72소시교대조조저，차이유통계학의의（ t치분별위4．832，5．233，3．343，P＜0．05）。결론혈액관류대잡마서평급성중독유명현료효，능쾌속강저잡마서평농도。
Objective To analyze the value of hemoperfusion in children with acute carbamazepine poisoning and summarize therapeutic experience.Methods From May 2007 to July 2013 totally 45 children were admitted in Xi ’ an Children ’ s Hospital for mistaking carbamazepine and their plasma concentration >15μg/mL.Twenty-four of them were divided into hemoperfusion group and 21 in control group.The hemoperfusion group was treated with hemoperfusion based on routine therapy .The serum carbamazepine concentrations of two groups were determined at 0h, 24h, 48h and 72h.Results The serum carbamazepine concentrations of the hemoperfusion group at 0h, 24h, 48h and 72h were 38.52 ±23.42μg/mL, 17.54 ±5.56μg/mL, 9.80 ±2.90μg/mL and 1.20 ±1.03μg/mL, respectively, while they were 35.52 ±5.56μg/mL, 30.92 ±5.53μg/mL, 24.38 ±4.44μg/mL and 16.52 ±4.23μg/mL, respectively in the control group.Compared with the control group , the serum carbamazepine concentrations of the hemoperfusion group were lower at 24h, 48h and 72h, and the differences were significant (t value was 4.832, 5.233 and 3.343, respectively, all P<0.05).Conclusion Hemoperfusion is an effective method for acute carbamazepine poisoning , which can quickly reduce the concentration of carbamazepine .